When is enough enough? Odds of survival by unit transfused

AM Loudon, AP Rushing, JJ Hue… - Journal of Trauma …, 2023 - journals.lww.com
BACKGROUND Balanced transfusion is lifesaving for hemorrhagic shock. The American
Red Cross critical blood shortage in 2022 threatened the immediate availability of blood. To …

Benefit of balance? Odds of survival by unit transfused: Retrospective analysis of the ACS-TQIP database

AM Loudon, AP Rushing, A Badrinathan, ML Moorman - Surgery, 2024 - Elsevier
Background The critical blood shortage in January 2022 threatened the availability of blood.
Utility of transfusion per unit was reported in a previous study, revealing patients receiving …

Cresting mortality: defining a plateau in ongoing massive transfusion

MT Quintana, JA Zebley, A Vincent… - Journal of Trauma …, 2022 - journals.lww.com
BACKGROUND Blood-based balanced resuscitation is a standard of care in massively
bleeding trauma patients. No data exist as to when this therapy no longer significantly affects …

Do not forget the platelets: the independent impact of red blood cell to platelet ratio on mortality in massively transfused trauma patients

AD Gallastegi, L Naar, A Gaitanidis… - Journal of Trauma …, 2022 - journals.lww.com
BACKGROUND Balanced blood component administration during massive transfusion is
standard of care. Most literature focuses on the impact of red blood cell (RBC)/fresh frozen …

Blood utilization and thresholds for mortality following major trauma

AB Schneider, U Adams, J Gallaher, LN Purcell… - Journal of Surgical …, 2023 - Elsevier
Introduction Blood loss is a hallmark of traumatic injury. Massive transfusion, historically
defined as the replacement by transfusion of 10 units of packed red blood cells (PRBCs) in 4 …

Outcomes after ultramassive transfusion in the modern era: an Eastern Association for the Surgery of Trauma multicenter study

ZA Matthay, ZJ Hellmann, RA Callcut… - Journal of Trauma …, 2021 - journals.lww.com
BACKGROUND Despite the widespread institution of modern massive transfusion protocols
with balanced blood product ratios, survival for patients with traumatic hemorrhage receiving …

Balanced blood component resuscitation in trauma: Does it matter equally at different transfusion volumes?

A Dorken-Gallastegi, AM Renne, M Bokenkamp… - Surgery, 2023 - Elsevier
Background It remains unclear whether the association between balanced blood component
transfusion and lower mortality is generalizable to trauma patients receiving varying …

Over‐transfusion with blood for suspected hemorrhagic shock is not associated with worse clinical outcomes

RB Gelbard, RL Griffin, L Reynolds, P Abraham… - …, 2022 - Wiley Online Library
Background We evaluated patient outcomes after early, small volume red blood cell (RBC)
transfusion in the setting of presumed hemorrhagic shock. We hypothesized that transfusion …

Transfusion of plasma, platelets, and red blood cells in a 1: 1: 1 vs a 1: 1: 2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial

JB Holcomb, BC Tilley, S Baraniuk, EE Fox, CE Wade… - Jama, 2015 - jamanetwork.com
Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

The reports of my death are greatly exaggerated: an evaluation of futility cut points in massive transfusion

TW Clements, JM Van Gent, DE Lubkin… - Journal of Trauma …, 2023 - journals.lww.com
BACKGROUND Following COVID and the subsequent blood shortage, several investigators
evaluated futility cut points in massive transfusion. We hypothesized that early aggressive …