Introduction Excessive activity of neutrophil elastase (NE), the main enzyme present in
azurophil granules in the neutrophil cytoplasm, may cause tissue injury and remodeling in …

In many respiratory diseases characterized by an intense inflammatory response, the
balance between proteolytic enzymes (proteases, including elastases) and their inhibitors …

Acute respiratory distress syndrome is a serious condition that can arise following direct or
indirect lung injury. It is heterogeneous and has a high mortality rate. Supportive care is the …

We conducted clinical trials in patients with acute lung injury (ALI) associated with systemic
inflammatory response syndrome using a selective neutrophil elastase inhibitor, sivelestat …

Objectives To review the evidence and rationale that suggest that neutrophil elastase (NE)
may contribute to the development of acute lung injury (ALI) and the acute respiratory …

Introduction Sivelestat is neutrophil elastase inhibitor, which is widely used in Japan for the
treatment of acute lung injury. However, the clinical efficacy of the medication has not been …

Background and objective: Neutrophil elastase (NE) may play a key role in the development
of acute lung injury (ALI) or ARDS. NE activity (NEA) was measured in patients with ALI …

Acute respiratory distress syndrome (ARDS) is a serious condition that can arise following
direct or indirect acute lung injury (ALI). It is heterogeneous and has a high mortality rate …

INTRODUCTION: Sivelestat, a neutrophil elastase inhibitor, has been approved in Japan for
the treatment of patients with acute lung injury (ALI) associated with systemic inflammatory …

Background and objective: Neutrophil elastase has been identified as a potential
therapeutic target for acute lung injury or acute respiratory distress syndrome, and Sivelestat …