Made in the womb: maternal programming of offspring cardiovascular function by an obesogenic womb

MS Diniz, LF Grilo, C Tocantins, I Falcão-Pires… - Metabolites, 2023 - mdpi.com
Obesity incidence has been increasing at an alarming rate, especially in women of
reproductive age. It is estimated that 50% of pregnancies occur in overweight or obese …

Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring

I Inzani, SE Ozanne - Proceedings of the Nutrition Society, 2022 - cambridge.org
There is an ever increasing prevalence of maternal obesity worldwide such that in many
populations over half of women enter pregnancy either overweight or obese. This review …

Maternal obesity: A focus on maternal interventions to improve health of offspring

A Shrestha, M Prowak, VM Berlandi-Short… - Frontiers in …, 2021 - frontiersin.org
Maternal obesity has many implications for offspring health that persist throughout their
lifespan that include obesity and cardiovascular complications. Several different factors …

The Endocrine–Metabolic Axis Regulation in Offspring Exposed to Maternal Obesity—Cause or Consequence in Metabolic Disease Programming?

LF Grilo, MS Diniz, C Tocantins, AL Areia, SP Pereira - Obesities, 2022 - mdpi.com
Obesity incidence is rising worldwide, including women of reproductive age, contributing to
increased gestations in which Maternal Obesity (MO) occurs. Offspring born to obese …

Impact of maternal obesity on fetal programming of cardiovascular disease

VHJ Roberts, AE Frias, KL Grove - Physiology, 2015 - journals.physiology.org
The in utero environment is a key determinant of long-term health outcomes; poor maternal
metabolic state and placental insufficiency are strongly associated with these long-term …

A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance

JLA Ferey, AL Boudoures, M Reid… - American Journal …, 2019 - journals.physiology.org
Maternal obesity is correlated with cardiovascular disease in offspring, with a 1.3-fold
increase in events observed in offspring of obese women. We have observed that obesity …

Maternal diet-induced obesity programmes cardiac dysfunction in male mice independently of post-weaning diet

E Loche, HL Blackmore, AA Carpenter… - Cardiovascular …, 2018 - academic.oup.com
Aims Obesity during pregnancy increases risk of cardiovascular disease (CVD) in the
offspring and individuals exposed to over-nutrition during fetal life are likely to be exposed to …

The epidemiology and mechanisms of lifetime cardiopulmonary morbidities associated with pre-pregnancy obesity and excessive gestational weight gain

S Rastogi, D Rastogi - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
Obesity has reached pandemic proportions in the last few decades. The global increase in
obesity has contributed to an increase in the number of pregnant women with pre-pregnancy …

Maternal obesity, lipotoxicity and cardiovascular diseases in offspring

M Dong, Q Zheng, SP Ford, PW Nathanielsz… - Journal of Molecular and …, 2013 - Elsevier
Maternal obesity has risen dramatically over the past 20years, by nearly 42% in African-
Americans and 29% in Caucasians. Maternal obesity is afflicted with many maternal …

Maternal diet-induced obesity and offspring cardiovascular health

HL Blackmore, SE Ozanne - … of developmental origins of health and …, 2013 - cambridge.org
It is widely recognized that environmental insults during adulthood including smoking, lack
of exercise and a poor diet increases an individual's risk of cardiovascular disease (CVD) …