Gene expression programs are regulated by enhancers which act in a context-specific
manner, and can reside at great distances from their target genes. Extensive three …

Epigenetic alteration is a major driver of cellular senescence and cancer, and the
reversibility of epigenetic modifications provides a highly optimistic avenue for anti …

Human life expectancy is constantly increasing and aging has become a major risk factor for
many diseases, although the underlying gene regulatory mechanisms are still unclear …

A mechanistic connection between aging and development is largely unexplored. Through
profiling age-related chromatin and transcriptional changes across 22 murine cell types …

Background Cellular senescence is a permanent state of replicative arrest defined by a
specific pattern of gene expression. The epigenome in senescent cells is sculptured in order …

The three-dimensional configuration of the chromatin architecture is known to be crucial for
alterations in the transcriptional network; however, the underlying mechanisms of epigenetic …

Aging is characterized by the interlocking decay of biological functions over time.
Microarrays have been successful in elucidating some of the genome-wide changes that …

Sustained exposure to a young systemic environment rejuvenates aged organisms and 1
promotes cellular function. However, due to the intrinsic complexity of tissues it remains 2 …

Organism aging occurs at the multicellular level; however, how pro-longevity mechanisms
slow down aging in different cell types remains unclear. We generated single-cell …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …