Metabolic engineering of thermophilic Bacillus methanolicus for riboflavin overproduction from methanol

VJ Klein, LF Brito, F Perez‐Garcia… - Microbial …, 2023 - Wiley Online Library
The growing need of next generation feedstocks for biotechnology spurs an intensification of
research on the utilization of methanol as carbon and energy source for biotechnological …

[HTML][HTML] Biotechnological strategies of riboflavin biosynthesis in microbes

JR Zhang, YY Ge, PH Liu, DT Wu, HY Liu, HB Li… - Engineering, 2022 - Elsevier
Riboflavin is an essential micronutrient for humans and must be obtained exogenously from
foods or supplements. Numerous studies have suggested a major role of riboflavin in the …

Metabolic engineering of Escherichia coli for the production of riboflavin

Z Lin, Z Xu, Y Li, Z Wang, T Chen, X Zhao - Microbial cell factories, 2014 - Springer
Abstract Background Riboflavin (vitamin B 2), the precursor of the flavin cofactors flavin
mononucleotide (FMN) and flavin adenine dinucleotide (FAD), is used commercially as an …

Metabolic engineering of Bacillus subtilis for enhancing riboflavin production by alleviating dissolved oxygen limitation

J You, C Yang, X Pan, M Hu, Y Du, T Osire, T Yang… - Bioresource …, 2021 - Elsevier
Riboflavin, an essential vitamin for animals, is used widely in the pharmaceutical industry
and as a food and feed additive. The microbial synthesis of riboflavin requires a large …

Metabolic engineering of Corynebacterium glutamicum for methanol metabolism

S Witthoff, K Schmitz, S Niedenführ, K Nöh… - Applied and …, 2015 - Am Soc Microbiol
Methanol is already an important carbon feedstock in the chemical industry, but it has found
only limited application in biotechnological production processes. This can be mostly …

Engineering thermophilic Geobacillus thermoglucosidasius for riboflavin production

Z Yang, Q Sun, G Tan, Q Zhang, Z Wang… - Microbial …, 2021 - Wiley Online Library
The potential advantages for fermentation production of chemicals at high temperatures are
attractive, such as promoting the rate of biochemical reactions, reducing the risk of …

Microbial production of riboflavin: biotechnological advances and perspectives

J You, X Pan, C Yang, Y Du, T Osire, T Yang… - Metabolic …, 2021 - Elsevier
Riboflavin is an essential nutrient for humans and animals, and its derivatives flavin
mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are cofactors in the cells …

Constructing a methanol-dependent Bacillus subtilis by engineering the methanol metabolism

B Gao, N Zhao, J Deng, Y Gu, S Jia, Y Hou, X Lv… - Journal of …, 2022 - Elsevier
Methanol is a promising green feedstock for producing fuels and chemicals because it is
inexpensive, clean, environmentally friendly, and easily prepared. Thus, many studies have …

Lactic acid bacteria as a cell factory for riboflavin production

K Thakur, SK Tomar, S De - Microbial biotechnology, 2016 - Wiley Online Library
Consumers are increasingly becoming aware of their health and nutritional requirements,
and in this context, vitamins produced in situ by microbes may suit their needs and …

Plasmid-Dependent Methylotrophy in Thermotolerant Bacillus methanolicus

T Brautaset, ØM Jakobsen, MC Flickinger… - Journal of …, 2004 - Am Soc Microbiol
Bacillus methanolicus can efficiently utilize methanol as a sole carbon source and has an
optimum growth temperature of 50° C. With the exception of mannitol, no sugars have been …