Aberrant kinase activity contributes to the pathogenesis of brain cancers,
neurodegeneration, and neuropsychiatric diseases, but identifying kinase inhibitors that …

Bioluminescence imaging (BLI) allows non-invasive visualization of cells and biochemical
events in vivo and thus has become an indispensable technique in biomedical research …

Mapping biological processes in brain tissues requires piecing together numerous
histological observations of multiple tissue samples. We present a direct method that …

Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is
very difficult to be completely excised by surgery due to its irregular shape. Here, we use an …

Cellular MRI involves sensitive visualization of iron-labeled cells in vivo but cannot
differentiate between dead and viable cells. Bioluminescence imaging (BLI) measures …

Background: Bioluminescence imaging (BLI) is one of the most widely used optical platforms
in molecular imaging, but it suffers from severe tissue attenuation and autoluminescence in …

Bioluminescent imaging (BLI) is a powerful tool in biomedical research to measure gene
expression and tumor growth. The current study examined factors that influence the BLI …

Primary brain tumors are hallmarked for their destructive activity on the microenvironment
and vasculature. However, solely few experimental techniques exist to access the tumor …

Glioblastoma (GBM) is an incurable brain cancer with a median survival of less than two
years from diagnosis. The standard treatment of GBM is multimodality therapy comprising …

Protein kinases control nearly every facet of cellular function. These key signaling nodes
integrate diverse pathway inputs to regulate complex physiological processes, and aberrant …