[PDF][PDF] Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity

DC Schreiner, A Wright, ET Baltz, T Wang, C Cazares… - Cell reports, 2023 - cell.com
Alcohol use disorder (AUD) alters decision-making control over actions, but disruptions to
the responsible neural circuit mechanisms are unclear. Premotor corticostriatal circuits are …

Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits

R Renteria, ET Baltz, CM Gremel - Nature communications, 2018 - nature.com
Addiction involves a predominance of habitual control mediated through action selection
processes in dorsal striatum. Research has largely focused on neural mechanisms …

[HTML][HTML] Chronic alcohol exposure differentially alters calcium activity of striatal cell populations during actions.

ET Baltz, R Renteria, CM Gremel - Addiction neuroscience, 2023 - Elsevier
Abstract Alcohol Use Disorder (AUD) can induce long lasting alterations to executive
function. This includes altered action control, which can manifest as dysfunctional goal …

[HTML][HTML] Augmented tendency to act and altered impulse control in alcohol use disorders

C Quoilin, P de Timary, J Duque - Neuroimage: clinical, 2021 - Elsevier
Action preparation relies on the operation of control processes that modulate the excitability
of the corticospinal tract. On the one hand, excitatory processes prepare the motor system for …

Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex

NM Timme, B Ma, D Linsenbardt, E Cornwell… - Nature …, 2022 - nature.com
A key feature of compulsive alcohol drinking is continuing to drink despite negative
consequences. To examine the changes in neural activity that underlie this behavior …

[HTML][HTML] Circuit dysfunctions of associative and sensorimotor basal ganglia loops in alcohol use disorder: Insights from animal models

G Sitzia, DM Lovinger - Addiction Neuroscience, 2023 - Elsevier
Abstract Persons that develop Alcohol Use Disorder (AUD) experience behavioral changes
that include compulsion to seek and take alcohol despite its negative consequences on the …

Neurobiological mechanisms of control in alcohol use disorder–Moving towards mechanism-based non-invasive brain stimulation treatments

F Ghin, C Beste, AK Stock - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Alcohol use disorder (AUD) is characterized by excessive habitual drinking and loss of
control over alcohol intake despite negative consequences. Both of these aspects foster …

Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol

J Weafer, SM Gorka, M Dzemidzic… - …, 2021 - nature.com
Poor inhibitory control and heightened feelings of stimulation after alcohol are two well-
established risk factors for alcohol use disorder (AUD). Although these risk factors have …

Different effects of alcohol exposure on action and outcome-related orbitofrontal cortex activity

C Cazares, DC Schreiner, CM Gremel - Eneuro, 2021 - eneuro.org
Alcohol dependence can result in long-lasting deficits to decision-making and action control.
Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for …

Reversal of alcohol-induced dysregulation in dopamine network dynamics may rescue maladaptive decision-making

AG Schindler, ME Soden, LS Zweifel… - Journal of …, 2016 - Soc Neuroscience
Alcohol is the most commonly abused substance among adolescents, promoting the
development of substance use disorders and compromised decision-making in adulthood …