[PDF][PDF] Chronic alcohol exposure alters action control via hyperactive premotor corticostriatal activity
Alcohol use disorder (AUD) alters decision-making control over actions, but disruptions to
the responsible neural circuit mechanisms are unclear. Premotor corticostriatal circuits are …
the responsible neural circuit mechanisms are unclear. Premotor corticostriatal circuits are …
Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
Addiction involves a predominance of habitual control mediated through action selection
processes in dorsal striatum. Research has largely focused on neural mechanisms …
processes in dorsal striatum. Research has largely focused on neural mechanisms …
[HTML][HTML] Chronic alcohol exposure differentially alters calcium activity of striatal cell populations during actions.
Abstract Alcohol Use Disorder (AUD) can induce long lasting alterations to executive
function. This includes altered action control, which can manifest as dysfunctional goal …
function. This includes altered action control, which can manifest as dysfunctional goal …
[HTML][HTML] Augmented tendency to act and altered impulse control in alcohol use disorders
Action preparation relies on the operation of control processes that modulate the excitability
of the corticospinal tract. On the one hand, excitatory processes prepare the motor system for …
of the corticospinal tract. On the one hand, excitatory processes prepare the motor system for …
Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex
NM Timme, B Ma, D Linsenbardt, E Cornwell… - Nature …, 2022 - nature.com
A key feature of compulsive alcohol drinking is continuing to drink despite negative
consequences. To examine the changes in neural activity that underlie this behavior …
consequences. To examine the changes in neural activity that underlie this behavior …
[HTML][HTML] Circuit dysfunctions of associative and sensorimotor basal ganglia loops in alcohol use disorder: Insights from animal models
G Sitzia, DM Lovinger - Addiction Neuroscience, 2023 - Elsevier
Abstract Persons that develop Alcohol Use Disorder (AUD) experience behavioral changes
that include compulsion to seek and take alcohol despite its negative consequences on the …
that include compulsion to seek and take alcohol despite its negative consequences on the …
Neurobiological mechanisms of control in alcohol use disorder–Moving towards mechanism-based non-invasive brain stimulation treatments
F Ghin, C Beste, AK Stock - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Alcohol use disorder (AUD) is characterized by excessive habitual drinking and loss of
control over alcohol intake despite negative consequences. Both of these aspects foster …
control over alcohol intake despite negative consequences. Both of these aspects foster …
Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol
Poor inhibitory control and heightened feelings of stimulation after alcohol are two well-
established risk factors for alcohol use disorder (AUD). Although these risk factors have …
established risk factors for alcohol use disorder (AUD). Although these risk factors have …
Different effects of alcohol exposure on action and outcome-related orbitofrontal cortex activity
Alcohol dependence can result in long-lasting deficits to decision-making and action control.
Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for …
Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for …
Reversal of alcohol-induced dysregulation in dopamine network dynamics may rescue maladaptive decision-making
Alcohol is the most commonly abused substance among adolescents, promoting the
development of substance use disorders and compromised decision-making in adulthood …
development of substance use disorders and compromised decision-making in adulthood …