Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI
Cushing's syndrome is an endocrine disorder caused by excess production of the stress
hormone cortisol. Precision medicine strategies have identified single allele mutations within …
hormone cortisol. Precision medicine strategies have identified single allele mutations within …
[HTML][HTML] Mislocalization of protein kinase A drives pathology in Cushing's syndrome
Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone
disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R …
disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R …
Alterations in protein kinase a substrate specificity as a potential cause of cushing syndrome
Cushing syndrome is a severe endocrine disorder of cortisol excess associated with major
metabolic and cardiovascular sequelae. We recently identified somatic mutations in …
metabolic and cardiovascular sequelae. We recently identified somatic mutations in …
Discovery of a Cushing's syndrome protein kinase A mutant that biases signaling through type I AKAPs
Adrenal Cushing's syndrome is a disease of cortisol hypersecretion often caused by
mutations in protein kinase A catalytic subunit (PKAc). Using a personalized medicine …
mutations in protein kinase A catalytic subunit (PKAc). Using a personalized medicine …
Is disrupted nucleotide-Substrate cooperativity a common trait for Cushing's syndrome driving mutations of protein kinase A?
Somatic mutations in the PRKACA gene encoding the catalytic α subunit of protein kinase A
(PKA-C) are responsible for cortisol-producing adrenocortical adenomas. These benign …
(PKA-C) are responsible for cortisol-producing adrenocortical adenomas. These benign …
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study
Context: Somatic mutations in PRKACA gene, encoding the catalytic subunit of protein
kinase A (PKA), have been recently found in a high proportion of sporadic adenomas …
kinase A (PKA), have been recently found in a high proportion of sporadic adenomas …
Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome
F Beuschlein, M Fassnacht, G Assié… - … England Journal of …, 2014 - Mass Medical Soc
Background Corticotropin-independent Cushing's syndrome is caused by tumors or
hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal …
hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal …
Mechanisms of aberrant PKA activation by Cα subunit mutations
D Calebiro, K Bathon, I Weigand - Hormone and Metabolic …, 2017 - thieme-connect.com
Somatic mutations in PRKACA, coding for the catalytic α subunit of protein kinase A (PKA),
have been recently identified as the most frequent genetic alteration in cortisol-secreting …
have been recently identified as the most frequent genetic alteration in cortisol-secreting …
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity
Genetic alterations in the PRKACA gene coding for the catalytic α subunit of the cAMP-
dependent protein kinase A (PKA-C) are linked to cortisol-secreting adrenocortical …
dependent protein kinase A (PKA-C) are linked to cortisol-secreting adrenocortical …
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome
Y Sato, S Maekawa, R Ishii, M Sanada, T Morikawa… - Science, 2014 - science.org
Cushing's syndrome is caused by excess cortisol production from the adrenocortical gland.
In corticotropin-independent Cushing's syndrome, the excess cortisol production is primarily …
In corticotropin-independent Cushing's syndrome, the excess cortisol production is primarily …