IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors

I Pitha, L Du, T Nguyen, H Quigley - Progress in retinal and eye research, 2023 - Elsevier
There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …

[PDF][PDF] Biomechanical changes of the optic disc

IA Sigal, MD Roberts, M Girard… - Ocular disease …, 2010 - ocularbiomechanics.com
Lowering intraocular pressure (IOP) remains the only proven method of preventing the onset
and progression of glaucoma, yet the role of IOP in the disease remains controversial. This …

Mechanical environment of the optic nerve head in glaucoma

JC Downs, MD Roberts… - Optometry and Vision …, 2008 - journals.lww.com
The optic nerve head (ONH) is of particular interest from a biomechanical perspective
because it is a weak spot within an otherwise strong corneo-scleral envelope. The lamina …

How does lowering of intraocular pressure protect the optic nerve?

P Mackenzie, G Cioffi - Survey of ophthalmology, 2008 - Elsevier
Until recently, the evidence that lowering intraocular pressure (IOP) protects the optic nerve
from glaucomatous damage was weak. Several randomized controlled trials have provided …

Biological aspects of axonal damage in glaucoma: a brief review

ER Tamm, CR Ethier, JE Dowling, C Downs… - Experimental eye …, 2017 - Elsevier
Intraocular pressure (IOP) is a critical risk factor in glaucoma, and the available evidence
derived from experimental studies in primates and rodents strongly indicates that the site of …

Biomechanical aspects of axonal damage in glaucoma: A brief review

C Stowell, CF Burgoyne, ER Tamm, CR Ethier… - Experimental eye …, 2017 - Elsevier
The biomechanical environment within the optic nerve head (ONH) is complex and is likely
directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our …

IOP: The importance of intraocular pressure

DR Anderson - Pearls of Glaucoma Management, 2016 - Springer
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Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma

JC Morrison, WOCY Guo, EC Johnson - Experimental eye research, 2011 - Elsevier
Understanding mechanisms of glaucomatous optic nerve damage is essential for
developing effective therapies to augment conventional pressure-lowering treatments. This …

The connective tissue phenotype of glaucomatous cupping in the monkey eye-Clinical and research implications

H Yang, J Reynaud, H Lockwood, G Williams… - Progress in retinal and …, 2017 - Elsevier
In a series of previous publications we have proposed a framework for conceptualizing the
optic nerve head (ONH) as a biomechanical structure. That framework proposes important …

IOP Homeostasis-Why most people do not ever develop glaucoma

TS Acott, MJ Kelley, KE Keller, JA Vranka… - Glaucoma Research …, 2016 - books.google.com
Although the glaucomas comprise a relatively common group of blinding diseases, only a
small percentage of people actually develop glaucoma, even at advanced age. Since …