Gut microbiota‐derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling
LW Liu, Y Xie, GQ Li, T Zhang, YH Sui… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Gut microbiota dysbiosis induced by acute pancreatitis (AP)
exacerbates pancreatic injury and systemic inflammatory responses. The alleviation of gut …
exacerbates pancreatic injury and systemic inflammatory responses. The alleviation of gut …
Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice
Y Zhu, C He, X Li, Y Cai, J Hu, Y Liao, J Zhao… - Journal of …, 2019 - Springer
Background The gut is implicated in the pathogenesis of acute pancreatitis (AP) and the
infectious complications of AP are commonly associated with enteric bacteria, yet whether …
infectious complications of AP are commonly associated with enteric bacteria, yet whether …
Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis
G Li, L Liu, T Lu, Y Sui, C Zhang, Y Wang… - Nature …, 2023 - nature.com
Hypertriglyceridemic pancreatitis (HTGP) is featured by higher incidence of complications
and poor clinical outcomes. Gut microbiota dysbiosis is associated with pancreatic injury in …
and poor clinical outcomes. Gut microbiota dysbiosis is associated with pancreatic injury in …
Paneth cells protect against acute pancreatitis Via modulating gut microbiota dysbiosis
Y Fu, Q Mei, N Yin, Z Huang, B Li, S Luo, B Xu, J Fan… - Msystems, 2022 - Am Soc Microbiol
Acute pancreatitis (AP) is usually accompanied by intestinal failure, but its mechanism is still
unclear. In AP patients, the functions of Paneth cells (lysozyme, HD5, Reg3γ, and Wnt3a) …
unclear. In AP patients, the functions of Paneth cells (lysozyme, HD5, Reg3γ, and Wnt3a) …
Gut microbiota affects pancreatic fibrotic progression through immune modulation in chronic pancreatitis
L Liu, T Zhang, Y Sui, G Li, L Liu, T Lu, H Tan… - Microbial …, 2023 - Elsevier
Chronic pancreatitis (CP) is characterized by chronic progressive pancreatic inflammation,
which leads to the permanent damage of exocrine and endocrine cells. CP causes …
which leads to the permanent damage of exocrine and endocrine cells. CP causes …
[HTML][HTML] Improvement of gut microbiota by inhibition of P38 mitogen-activated protein kinase (MAPK) signaling pathway in rats with severe acute pancreatitis
YD Wan, RX Zhu, ZZ Bian, XT Pan - Medical Science Monitor …, 2019 - ncbi.nlm.nih.gov
Background Gut microbiota dysbiosis plays a key role in pathogenesis of severe acute
pancreatitis (SAP). In this study, we explored the protective effects of the p38 MAPK inhibitor …
pancreatitis (SAP). In this study, we explored the protective effects of the p38 MAPK inhibitor …
The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice
X Li, C He, N Li, L Ding, H Chen, J Wan, X Yang… - Gut …, 2020 - Taylor & Francis
Early dysbiosis of the gut microbiota is associated with the severity of acute pancreatitis
(AP), although the underlying mechanism is unclear. Here, we investigated the role of …
(AP), although the underlying mechanism is unclear. Here, we investigated the role of …
Gut microbiota interacts with inflammatory responses in acute pancreatitis
L Wu, J Hu, X Yi, J Lv, J Yao, W Tang… - Therapeutic …, 2023 - journals.sagepub.com
Acute pancreatitis (AP) is one of the most common acute abdominal conditions, and its
incidence has been increasing for years. Approximately 15–20% of patients develop severe …
incidence has been increasing for years. Approximately 15–20% of patients develop severe …
Saikosaponin A‐Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1/Nrf2‐ARE Antioxidant Signaling
J Li, J Han, J Lv, S Wang, L Qu… - Oxidative Medicine and …, 2020 - Wiley Online Library
Objective. Severe acute pancreatitis (SAP) is a serious and life‐threatening disease
associated with multiple organ failure and a high mortality rate and is accompanied by …
associated with multiple organ failure and a high mortality rate and is accompanied by …
Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate
FF van den Berg, D van Dalen, SK Hyoju… - Gut, 2021 - gut.bmj.com
Objective The gut microbiota are the main source of infections in necrotising pancreatitis. We
investigated the effect of disruption of the intestinal microbiota by a Western-type diet on …
investigated the effect of disruption of the intestinal microbiota by a Western-type diet on …