Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis
DLW Chong, TA Mikolasch, J Sahota… - … of Physiology-Lung …, 2023 - journals.physiology.org
Transforming growth factor-β1 (TGFβ1) is the key profibrotic cytokine in idiopathic pulmonary
fibrosis (IPF), but the primary source of this cytokine in this disease is unknown. Platelets …
fibrosis (IPF), but the primary source of this cytokine in this disease is unknown. Platelets …
[HTML][HTML] Host predisposition by endogenous Transforming Growth Factor-β1 overexpression promotes pulmonary fibrosis following bleomycin injury
Y Haider, AP Malizia, DT Keating, M Birch… - Journal of …, 2007 - Springer
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a progressive diffuse disease
involving the lung parenchyma. Despite recent advances, the molecular mechanisms of the …
involving the lung parenchyma. Despite recent advances, the molecular mechanisms of the …
[HTML][HTML] Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling
RD Guzy, L Li, C Smith, SJ Dorry, HY Koo… - Journal of Biological …, 2017 - ASBMB
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive pulmonary scarring,
decline in lung function, and often results in death within 3–5 five years after diagnosis …
decline in lung function, and often results in death within 3–5 five years after diagnosis …
[HTML][HTML] Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis
M Li, MS Krishnaveni, C Li, B Zhou… - The Journal of …, 2011 - Am Soc Clin Investig
Idiopathic pulmonary fibrosis (IPF) is a chronic fibroproliferative pulmonary disorder for
which there are currently no treatments. Although the etiology of IPF is unknown …
which there are currently no treatments. Although the etiology of IPF is unknown …
Cytokine profiles in idiopathic pulmonary fibrosis suggest an important role for TGF‐β and IL-10
A Bergeron, P Soler, M Kambouchner… - European …, 2003 - Eur Respiratory Soc
Modulation of cytokine expression represents a potentially useful approach for the treatment
of idiopathic pulmonary fibrosis (IPF). To identify potential targets for such intervention, semi …
of idiopathic pulmonary fibrosis (IPF). To identify potential targets for such intervention, semi …
Fibroblast growth factor‐1 attenuates TGF‐β1‐induced lung fibrosis
C Shimbori, PS Bellaye, J Xia, J Gauldie… - The Journal of …, 2016 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibroblast and
myofibroblast proliferation, and extensive deposition of extracellular matrix (ECM). Fibroblast …
myofibroblast proliferation, and extensive deposition of extracellular matrix (ECM). Fibroblast …
[HTML][HTML] Blockade of platelet-derived growth factor receptor-β, not receptor-α ameliorates bleomycin-induced pulmonary fibrosis in mice
M Kishi, Y Aono, S Sato, K Koyama, M Azuma, S Abe… - PloS one, 2018 - journals.plos.org
Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of pulmonary
fibrosis. Nintedanib, a multi-kinase inhibitor that targets several tyrosine kinases, including …
fibrosis. Nintedanib, a multi-kinase inhibitor that targets several tyrosine kinases, including …
[HTML][HTML] Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor
Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial
lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly …
lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly …
[HTML][HTML] TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling
G Epstein Shochet, E Brook, B Bardenstein-Wald… - Respiratory …, 2020 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease
characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are …
characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are …
Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β
Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by fibroblast
proliferation and excess deposition of collagen and other extracellular matrix (ECM) …
proliferation and excess deposition of collagen and other extracellular matrix (ECM) …