[PDF][PDF] Next-generation immunotherapy to counteract T-cell exhaustion
D Nixdorf - 2023 - edoc.ub.uni-muenchen.de
CAR T-cell therapies have revolutionized the treatment of various B-cell malignancies [1–3].
Although allogeneic stem cell transplantation first demonstrated the power of adoptive T-cell …
Although allogeneic stem cell transplantation first demonstrated the power of adoptive T-cell …
Determinants of response and resistance to CAR T cell therapy
The remarkable success of chimeric antigen receptor (CAR)-engineered T cells in pre-B cell
acute lymphoblastic leukemia (ALL) and B cell lymphoma led to the approval of anti-CD19 …
acute lymphoblastic leukemia (ALL) and B cell lymphoma led to the approval of anti-CD19 …
Bispecific CAR T-cells for B-cell malignancies
Introduction Chimeric antigen receptor (CAR)-modified T-cell therapy has revolutionized the
treatment of relapsed/refractory B-cell malignancies including acute lymphoblastic leukemia …
treatment of relapsed/refractory B-cell malignancies including acute lymphoblastic leukemia …
CAR as Booster to Launch Allogeneic Transplantation in Refractory Leukemia
D Blaise - New England Journal of Medicine, 2024 - Mass Medical Soc
Chimeric antigen receptor (CAR) T-cell therapies have revolutionized the treatment
landscape for patients with relapsed or refractory B-cell lymphoid cancers. 1 With studies …
landscape for patients with relapsed or refractory B-cell lymphoid cancers. 1 With studies …
INSPIRED Symposium Part 5: Expanding the Use of CAR T cells in Children and Young Adults
Chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable efficacy in
relapsed/refractory (r/r) B cell malignancies, including in pediatric patients with acute …
relapsed/refractory (r/r) B cell malignancies, including in pediatric patients with acute …
Allogeneic CAR T cell therapies for leukemia
W Qasim - American journal of hematology, 2019 - Wiley Online Library
Allogeneic chimeric antigen receptor T (CAR T) cells can offer advantages over autologous
T cell therapies, including the availability of “fit” cells for production, and elimination of risks …
T cell therapies, including the availability of “fit” cells for production, and elimination of risks …
Charting new paradigms for CAR-T cell therapy beyond current Achilles heels
Y Li, Z Hu, Y Li, X Wu - Frontiers in Immunology, 2024 - frontiersin.org
Chimeric antigen receptor-T (CAR-T) cell therapy has made remarkable strides in treating
hematological malignancies. However, the widespread adoption of CAR-T cell therapy is …
hematological malignancies. However, the widespread adoption of CAR-T cell therapy is …
[HTML][HTML] CAR-T cell therapy in hematological malignancies: current opportunities and challenges
X Zhang, L Zhu, H Zhang, S Chen, Y Xiao - Frontiers in immunology, 2022 - frontiersin.org
Chimeric antigen receptor T (CAR-T) cell therapy represents a major breakthrough in cancer
treatment, and it has achieved unprecedented success in hematological malignancies …
treatment, and it has achieved unprecedented success in hematological malignancies …
[HTML][HTML] Enhancing CAR T-cell therapies against solid tumors: Mechanisms and reversion of resistance
Y Qin, G Xu - Frontiers in Immunology, 2022 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell therapy, belonging to adoptive immune cells
therapy, utilizes engineered immunoreceptors to enhance tumor-specific killing. By now new …
therapy, utilizes engineered immunoreceptors to enhance tumor-specific killing. By now new …
[HTML][HTML] CAR-T Cell therapy in T-cell malignancies: limitations and solutions
L Shan, X Feng, J Pan - Hematology and Oncology Discovery, 2022 - scienceopen.com
CD19-targeted chimeric antigen receptor (CAR)-T cell therapy has shown high potential for
treating B-cell hematological malignancies and has been approved by the US FDA …
treating B-cell hematological malignancies and has been approved by the US FDA …