Glioblastoma (GBM) is the most frequent and lethal brain tumor, whose therapeutic outcome-
only partially effective with current schemes-places this disease among the unmet medical …

Glioblastoma (GBM) is the most prevalent malignant tumor in the central nervous system.
Aerobic glycolysis, featured with elevated glucose consumption and lactate production …

In the last few years, several efforts have been made to identify original strategies against
glioblastoma multiforme (GBM): this requires a more detailed investigation of the molecular …

Pyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway,
generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP precursors. In …

Abstract Background Glioblastoma (GBM; grade IV glioma) is characterized by a very short
overall survival time and extremely low 5-year survival rates. We intend to promote …

Background Glioma is the most common and primary brain tumors in adults. Despite the
available multimodal therapies, glioma patients appear to have a poor prognosis. The …

Cancer metabolism has emerged as an increasingly attractive target for interfering with
tumor growth. Small molecule activators of pyruvate kinase isozyme M2 (PKM2) suppress …

Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of
aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue …

Recent findings show that exposure to temozolomide (TMZ), a DNA-damaging drug used to
treat glioblastoma (GBM), can suppress the conversion of pyruvate to lactate. To understand …

Glioblastoma (GBM) is the most common and aggressive brain tumour of adults. The
metabolic phenotype of GBM cells is highly dependent on glycolysis; therefore, therapeutic …