Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

Pseudomonas aeruginosa is a major opportunistic pathogen that exhibits high-level intrinsic
and acquired multiple antimicrobial resistance. In addition to the accumulation of individual …

Transporters of the resistance-nodulation-cell division (RND) superfamily of proteins are the
dominant multidrug efflux power of Gram-negative bacteria. The major RND efflux pump of …

Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens.
Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 …

The resistance-nodulation-division (RND) family multidrug efflux system MexXY-OprM is a
major determinant of aminoglycoside resistance in Pseudomonas aeruginosa, although the …

Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

Gram‐negative bacteria remain clinically important pathogens in both hospital and
community settings. Recent research indicates that efflux pumps play a prominent role in the …

To identify the optimal pharmacodynamic exposures of meropenem, imipenem, and
cefepime, and the emergence of resistance in vivo for Pseudomonas aeruginosa …

Pseudomonas aeruginosa is an opportunistic human pathogen characterized by an innate
resistance to multiple antimicrobial agents. A major contribution to this intrinsic multidrug …

ABSTRACT Resistance-nodulation-division (RND) efflux pumps are important contributors
to bacterial antibiotic resistance. In this study, we combined evolutionary sequence …