Atherosclerosis (AS) is a chronic inflammatory vascular disease, and aging is a major risk
factor. The accumulation of senescent vascular endothelial cells (VECs) often leads to …

Vascular smooth muscle cells (VSMCs) are the primary cell type involved in the
atherosclerosis process; senescent VSMCs are observed in both aged vessels and …

Inflammation is a hallmark and potent driver of pathological vascular remodelling in
atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown …

Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the
physiopathology of atherosclerosis are cellular senescence, oxidative stress, and …

Objective—Vascular smooth muscle cells (VSMCs) that become senescent are both present
within atherosclerotic plaques and thought to be important to the disease process. However …

Senescence of endothelial cells increases with systemic aging and is thought to contribute
to the development of atherosclerosis. Cell therapy with highly proliferative endothelial …

The aging process is associated with a loss of complexity in the dynamics of physiological
systems that reduce the ability to adapt to stress, causing frailty and/or age-related diseases …

Cardiovascular diseases are a serious threat to human health, especially in the elderly.
Vascular aging makes people more susceptible to cardiovascular diseases due to …

Aging is the main risk factor for cardiovascular diseases (CVD), and senescence in
endothelial cells seems to be an initial step in the cascade of events that will culminate with …