[HTML][HTML] Sustained secretion of human growth hormone from TheraCyte devices encapsulated with PiggyBac-engineered retinal pigment epithelium cells
CR Cecchi, S Alsing, GPP Jesus, EA Zacarias, L Kjaer… - Tissue and Cell, 2023 - Elsevier
Growth hormone (GH) deficiency is characterized by impaired growth and development, and
is currently treated by repeated administration of recombinant human GH (hGH) …
is currently treated by repeated administration of recombinant human GH (hGH) …
ARPE-19 as a Platform Cell Line for Encapsulated Cell-Based Delivery
W Tao, DH Rein, BJ Dean, PF Stabila… - US Patent App. 12 …, 2009 - Google Patents
(57) ABSTRACT ARPE-19 cells were evaluated as a platform cell line for encapsulated and
unencapsulated cell-based delivery tech nology. ARPE-19 cells were found to be hardy (the …
unencapsulated cell-based delivery tech nology. ARPE-19 cells were found to be hardy (the …
In vivo delivery of recombinant human growth hormone from genetically engineered human fibroblasts implanted within Baxter immunoisolation devices
SF Josephs, T Loudovaris, A Dixit, SK Young… - Journal of molecular …, 1999 - Springer
Continuous delivery of therapeutic peptide to the systemic circulation would be the optimal
treatment for a variety of diseases. The Baxter TheraCyte® system is a membrane …
treatment for a variety of diseases. The Baxter TheraCyte® system is a membrane …
Long-term erythropoietin gene expression from transduced cells in bioisolator devices
O Yanay, SC Barry, LY Flint, M Brzezinski… - Human gene …, 2003 - liebertpub.com
Recombinant erythropoietin (EPO) is widely administered for long-term treatment of anemia
associated with renal failure and other chronic diseases. The ability to deliver EPO by gene …
associated with renal failure and other chronic diseases. The ability to deliver EPO by gene …
Long-term expression of human growth hormone (hGH) in mice containing allogeneic yolk sac cell derived neovascular implants expressing hGH
Y Wei, J Li, TE Wagner - Stem Cells, 1996 - academic.oup.com
We have established a systemic gene delivery animal model system by using cultured
murine embryonic yolk sac cells, which can be easily genetically modified in vitro and …
murine embryonic yolk sac cells, which can be easily genetically modified in vitro and …
[HTML][HTML] Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape
K Kirk, E Hao, R Lahmy, P Itkin-Ansari - Stem cell research, 2014 - Elsevier
There are several challenges to successful implementation of a cell therapy for insulin
dependent diabetes derived from human embryonic stem cells (hESC). Among these are …
dependent diabetes derived from human embryonic stem cells (hESC). Among these are …
A laboratory-scale device for the straightforward production of uniform, small sized cell microcapsules with long-term cell viability
LS Kontturi, M Yliperttula, P Toivanen, A Määttä… - Journal of controlled …, 2011 - Elsevier
Microencapsulated and genetically engineered cells may be used for prolonged delivery of
therapeutically active proteins. The objective of this study was to develop a simple …
therapeutically active proteins. The objective of this study was to develop a simple …
Preclinical and preliminary clinical evaluation of genetically transduced dermal tissue implants for the sustained secretion of erythropoietin and interferon α
N Shapir, R Miari, S Blum, D Schwartz… - Human Gene …, 2015 - liebertpub.com
Protein drugs are currently delivered by bolus injection and although treatment frequently is
successful, these methods also have major drawbacks, which call for the development of …
successful, these methods also have major drawbacks, which call for the development of …
Insulin-producing endocrine cells differentiated in vitro from human embryonic stem cells function in macroencapsulation devices in vivo
AD Agulnick, DM Ambruzs, MA Moorman… - Stem cells …, 2015 - academic.oup.com
The PEC-01 cell population, differentiated from human embryonic stem cells (hESCs),
contains pancreatic progenitors (PPs) that, when loaded into macroencapsulation devices …
contains pancreatic progenitors (PPs) that, when loaded into macroencapsulation devices …
A microfabricated scaffold for retinal progenitor cell grafting
Diseases that cause photoreceptor cell degeneration afflict millions of people, yet no
restorative treatment exists for these blinding disorders. Replacement of photoreceptors …
restorative treatment exists for these blinding disorders. Replacement of photoreceptors …