Neurodegeneration of the central nervous system (CNS) underscores many of humanity's
most debilitating diseases, including Alzheimer's disease, Parkinson's disease, and multiple …

Glaucoma is a progressive age-related disease of the visual system and the leading cause
of irreversible blindness worldwide. Currently, intraocular pressure (IOP) is the only …

The nitric oxide–guanylyl cyclase-1–cyclic guanylate monophosphate (NO-GC-1–cGMP)
pathway has emerged as a potential pathogenic mechanism for glaucoma, a common …

The nitric oxide–guanylyl cyclase-1–cyclic guanylate monophosphate (NO–GC-1–cGMP)
pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha …

Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs)
associated with characteristic axon degeneration in the optic nerve. Clinically, our only …

Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision
loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain …

Glaucoma is a prevalent optic neuropathy characterized by the progressive dysfunction and
loss of retinal ganglion cells (RGCs) and their optic nerve axons, which leads to irreversible …

Background Glaucoma is an optic neuropathy characterized by retinal ganglion cell
degeneration leading to vision loss. Primary open angle glaucoma is a subtype of glaucoma …

Background Glaucoma is a leading neurodegenerative disease affecting over 70 million
individuals worldwide. Early pathological events of axonal degeneration and retinopathy in …

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic
targets based on neuronal protection, repair, or regeneration, independent of etiology or site …