Objectives Antiepileptic and antiarrhythmic drugs inhibit voltage-gated sodium (Na+)
channels (VGSCs), and preclinical studies show that these medications reduce tumour …

Introduction Voltage-gated sodium channel (VGSC)-inhibiting drugs are commonly used to
treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers …

Introduction Metastasis from solid tumours is associated with significant morbidity and
mortality, and is the leading cause of cancer-related deaths. Voltage-gated sodium channels …

Metastasis is the leading cause of cancer-related deaths. Voltage-gated sodium channels
(VGSCs) regulate invasion and metastasis. Several VGSC-inhibiting drugs reduce …

Objective: To determine the exact role of sodium channel proteins in migration, invasion and
metastasis and understand the possible anti-invasion and anti-metastatic activity of …

Background Multi-faceted evidence from a range of cancers suggests strongly that de novo
expression of voltage-gated sodium channels (VGSCs) plays a significant role in driving …

Purpose: Voltage-gated sodium channels (VGSCs) are drug targets for the treatment of
epilepsy. Recently, a decreased risk of cancer associated with sodium channel-blocking …

The development of therapies that can suppress invasion and prevent metastasis,'anti-
metastatic drugs', is an important area of unmet therapeutic need. The new results of a …

Background Voltage‐gated sodium channels (VGSCs) are involved in several cellular
processes related to cancer cell growth and metastasis, including adhesion, proliferation …

Background High levels of voltage-gated sodium channels (VGSCs) have been previously
associated with the invasiveness of rat and human prostate cancer (Pca) cell lines. Materials …