Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

Cardiovascular diseases have become the leading cause of human death. Aging is an
independent risk factor for cardiovascular diseases. Cardiac aging is associated with …

Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Cardiac metabolism is highly adaptive to changes in fuel availability and the energy demand
of the heart. This metabolic flexibility is key for the heart to maintain its output during the …

Aims Heart failure is characterized by structural and metabolic cardiac remodelling. The aim
of the present study is to expand our understanding of the complex metabolic alterations in …

Medical advances and the availability of diagnostic tools have considerably increased life
expectancy and, consequently, the elderly segment of the world population. As age is a …

Cardiac aging is an intrinsic process that results in impaired cardiac function, along with
cellular and molecular changes. These degenerative changes are intimately associated with …

Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for developing cardiovascular disease because of the …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …