At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-
degrading endolysins that cause explosive cell lysis of the host can also attack non-infected …

In the billion years that bacteriophage (or phage) have existed together with bacteria the
phage have evolved systems that may be exploited for our benefit. One of these is the lytic …

The peptidoglycan cell wall is an essential structure for the growth of most bacteria.
However, many are capable of switching into a wall-deficient L-form state in which they are …

The intracellular pathogen Listeria monocytogenes is distinguished by its ability to invade
and replicate within mammalian cells. Remarkably, of the 15 serovars within the genus …

Phages are highly abundant in the environment and pose a major threat for bacteria.
Therefore, bacteria have evolved sophisticated defence systems to withstand phage attacks …

Most bacteriophages (phages) release their progeny through the action of holins that form
lesions in the cytoplasmic membrane and lysins that degrade the bacterial peptidoglycan …

Antibiotic resistance is rapidly spreading via the horizontal transfer of resistance genes in
mobile genetic elements. While plasmids are key drivers of this process, few integrative …

Listeria monocytogenes is an intracellular bacterial pathogen that replicates rapidly in the
cytosol of host cells during acute infection. Surprisingly, these bacteria were found to occupy …

Summary β-lactam antibiotics inhibit bacterial cell wall assembly and, under classical
microbiological culture conditions that are generally hypotonic, induce explosive cell death …

D29 mycobacteriophage encodes LysA endolysin, which mediates mycobacterial host cell
lysis by targeting its peptidoglycan layer, thus projecting itself as a potential therapeutic …