The poor aqueous solubility of many modern active pharmaceutical ingredients (APIs) can
severely limit bioavailability. Cocrystals are emerging as a promising means of overcoming …

Abstract Model-based optimization of cocrystallization processes involves the simultaneous
identification of the optimal coformer and solvent types and the process operating …

Co-crystallization is a promising strategy to enhance the water solubility and bioavailability
of active pharmaceutical ingredients (APIs). Once possible coformers have been identified …

Cocrystals are an emerging solid-state form to change physicochemical and
biopharmaceutical drug properties. This dissertation focuses on the thermodynamic stability …

Recently, the co-crystallization of pharmaceutical drugs is gaining consideration because it
is an environmentally friendly and potentially effective technique to improve the solubility …

Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

This study aims at easing the design of crystallization and the cake washing step of
cocrystals. It is assessed if solvent systems can be classified based on the dissolution …

Controlling the physical properties of solid forms for active pharmaceutical ingredients (APIs)
through cocrystallization is an important part of drug product development. However, it is …

Pharmaceutical cocrystals represent a distinctive class of crystal engineered
multicomponent systems consisting an API and a crystal former non-covalently linked …

Cocrystals have drawn a lot of research interest in the last decade due to their potential to
favorably alter the physicochemical and biopharmaceutical properties of active …