Epigenetics is the study of heritable changes in gene expression or function without altering
the DNA sequence. Important factors are part of epigenetic events, such as methylation …

In this chapter, the development of decitabine from its synthesis in 1964 to the submission of
a registration file in 2004 is reviewed. The proper application of the unique properties of …

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the
discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications …

Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

Tumor development is frequently accompanied by abnormal expression of multiple genomic
genes, which can be broadly viewed as decreased expression of tumor suppressor genes …

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …

Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …

Epigenetics studies heritable genomic modifications that occur with the participation of
epigenetic modifying enzymes but without alterations of the nucleotide structure. Small …

Epigenetic drug discovery field has evidenced significant advancement in the recent times.
A plethora of small molecule inhibitors have progressed to clinical stage investigations and …

Epigenetic modulation can affect the characteristics of cancers. Because it is likely to
manipulate epigenetic genes, they can be considered as potential targets for cancer …