Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia

X Li, L Lozovatsky, SM Tommasini, J Fretz… - Blood …, 2023 - ashpublications.org
Iron deficiency is a potent stimulator of fibroblast growth factor 23 (FGF23), a hormonal
regulator of phosphate and vitamin D metabolism, that is classically thought to be produced …

[HTML][HTML] Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production

V David, A Martin, T Isakova, C Spaulding, L Qi… - Kidney international, 2016 - Elsevier
Circulating levels of fibroblast growth factor 23 (FGF23) are elevated in patients with chronic
kidney disease (CKD), but the mechanisms are poorly understood. Here we tested whether …

Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice

A Daryadel, L Natale, P Seebeck, C Bettoni… - Scientific reports, 2019 - nature.com
Abstract Fibroblast Growth Factor 23 (FGF23) is a phosphaturic factor causing increased
renal phosphate excretion as well as suppression of 1, 25 (OH) 2-vitamin D3. Highly …

Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and men

A Daryadel, C Bettoni, T Haider… - … -European Journal of …, 2018 - Springer
Abstract Fibroblast growth factor 23 (FGF23) is a major endocrine regulator of phosphate
and 1, 25 (OH) 2 vitamin D 3 metabolism and is mainly produced by osteocytes. Its …

Regulation of fibroblast growth factor 23 by iron, EPO, and HIF

JA Wheeler, EL Clinkenbeard - Current molecular biology reports, 2019 - Springer
Abstract Purpose of Review Fibroblast growth factor-23 (FGF23) is the key hormone
produced in bone critical for phosphate homeostasis. Elevated serum phosphorus and 1, 25 …

FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis

LM Coe, SV Madathil, C Casu, B Lanske… - Journal of Biological …, 2014 - ASBMB
Abnormal blood cell production is associated with chronic kidney disease (CKD) and
cardiovascular disease (CVD). Bone-derived FGF-23 (fibroblast growth factor-23) regulates …

FGF-23 from erythroblasts promotes hematopoietic progenitor mobilization

S Ishii, T Suzuki, K Wakahashi, N Asada… - Blood, The Journal …, 2021 - ashpublications.org
Abstract Fibroblast growth factor 23 (FGF-23) hormone is produced by bone-embedded
osteocytes and regulates phosphate homeostasis in kidneys. We found that administration …

Crosstalk of fibroblast growth factor 23 and anemia‑related factors during the development and progression of CKD

R Zhang, SY Wang, F Yang, S Ma… - Experimental and …, 2021 - spandidos-publications.com
Abstract Fibroblast growth factor 23 (FGF23) plays an important role in the development of
chronic kidney disease‑mineral bone disorder (CKD‑MBD). Abnormally elevated levels of 1 …

Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease

M Wolf, KE White - Current opinion in nephrology and …, 2014 - journals.lww.com
Iron deficiency stimulates FGF23 production, but normal osteocytes couple increased FGF23
production with increased cleavage to maintain normal circulating levels of biologically …

Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women

M Wolf, TA Koch, DB Bregman - Journal of Bone and Mineral …, 2013 - academic.oup.com
ABSTRACT Fibroblast growth factor 23 (FGF23) is an osteocyte‐derived hormone that
regulates phosphate and vitamin D homeostasis. Through unknown mechanisms, certain …