BACKGROUND In the Study of Tranexamic Acid During Air and Ground Prehospital
Transport (STAAMP) Trial, prehospital tranexamic acid (TXA) was associated with lower …

Importance The early use of tranexamic acid (TXA) has demonstrated benefit among some
trauma patients in hemorrhagic shock. The association between TXA administration and …

Methods A secondary analysis was performed using harmonized data from two large,
double-blinded, randomized prehospital TXA trials. Outcomes, including 28-day mortality …

Importance In-hospital administration of tranexamic acid after injury improves outcomes in
patients at risk for hemorrhage. Data demonstrating the benefit and safety of the pragmatic …

Background Tranexamic acid (TXA) has been hypothesized to mitigate coagulopathy in
patients after traumatic injury. Despite previous prehospital clinical trials demonstrating a …

Background Tranexamic acid (TXA) has been shown to reduce mortality in the treatment of
traumatic hemorrhage. This effect seems most profound when given early after injury. We …

BACKGROUND Tranexamic acid (TXA) is used as a hemostatic adjunct for hemorrhage
control in the injured patient and reduces early preventable death. However, the risk of …

Introduction Tranexamic acid (TXA) has been shown to decrease mortality in adult trauma
patients with or at significant risk of hemorrhage when administered within 3 h of injury. The …

Hemorrhage and coagulopathy remain major drivers of early preventable mortality in military
and civilian trauma. The development of trauma-induced coagulopathy and hyperfibrinolysis …

Background: Tranexamic acid (TXA) administration is recommended in severely injured
trauma patients. We examined TXA administration, admission fibrinolysis phenotypes, and …