Regulation of G Protein-Gated Inwardly Rectifying K+ Channel Activity
KD Gada, R Mahajan, DE Logothetis - Textbook of Ion Channels Volume … - taylorfrancis.com
The βγ subunits of heterotrimeric G proteins (Gβγ) were shown in 1987 to directly activate
atrial K+ channels, underlying the acetylcholine-induced decrease in heart rate. In 2013 …
atrial K+ channels, underlying the acetylcholine-induced decrease in heart rate. In 2013 …
A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels
The atrial G protein (heterotrimeric guanine nucleotide–binding protein)–regulated inwardly
rectifying K+ (GIRK1 and GIRK4) heterotetrameric channels underlie the acetylcholine …
rectifying K+ (GIRK1 and GIRK4) heterotetrameric channels underlie the acetylcholine …
Use of a molecular switch probe to activate or inhibit GIRK1 heteromers in silico reveals a novel gating mechanism
G protein-gated inwardly rectifying K+ (GIRK) channels form highly active heterotetramers in
the body, such as in neurons (GIRK1/GIRK2 or GIRK1/2) and heart (GIRK1/GIRK4 or …
the body, such as in neurons (GIRK1/GIRK2 or GIRK1/2) and heart (GIRK1/GIRK4 or …
On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer
G protein–gated inwardly rectifying K+(GIRK) channels belong to the inward-rectifier K+(Kir)
family, are abundantly expressed in the heart and the brain, and require that …
family, are abundantly expressed in the heart and the brain, and require that …
NMR analyses of the Gβγ binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)
M Yokogawa, M Osawa, K Takeuchi, Y Mase… - Journal of Biological …, 2011 - ASBMB
G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in
regulating heart rate and neuronal excitability in eukaryotic cells. GIRK is activated by the …
regulating heart rate and neuronal excitability in eukaryotic cells. GIRK is activated by the …
Structural basis for modulation of gating property of G protein-gated inwardly rectifying potassium ion channel (GIRK) by i/o-family G protein α subunit (Gαi/o)
Y Mase, M Yokogawa, M Osawa, I Shimada - Journal of Biological …, 2012 - ASBMB
G protein-gated inwardly rectifying potassium channel (GIRK) plays a crucial role in
regulating heart rate and neuronal excitability. The gating of GIRK is regulated by the …
regulating heart rate and neuronal excitability. The gating of GIRK is regulated by the …
A switch mechanism for Gβγ activation of IKACh
I Medina, G Krapivinsky, S Arnold, P Kovoor… - Journal of Biological …, 2000 - ASBMB
G protein-gated inwardly rectifying potassium (GIRK) channels are a family of K+-selective
ion channels that slow the firing rate of neurons and cardiac myocytes. GIRK channels are …
ion channels that slow the firing rate of neurons and cardiac myocytes. GIRK channels are …
Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh
S Corey, G Krapivinsky, L Krapivinsky… - Journal of Biological …, 1998 - ASBMB
The G-protein-regulated, inwardly rectifying K+(GIRK) channels are critical for functions as
diverse as heart rate modulation and neuronal post-synaptic inhibition. GIRK channels are …
diverse as heart rate modulation and neuronal post-synaptic inhibition. GIRK channels are …
Identification of critical residues controlling G protein-gated inwardly rectifying K+ channel activity through interactions with the βγ subunits of G proteins
C He, X Yan, H Zhang, T Mirshahi, T Jin… - Journal of Biological …, 2002 - ASBMB
G protein-sensitive inwardly rectifying potassium (GIRK) channels are activated through
direct interactions of their cytoplasmic N-and C-terminal domains with the βγ subunits of G …
direct interactions of their cytoplasmic N-and C-terminal domains with the βγ subunits of G …
Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
H Kano, Y Toyama, S Imai, Y Iwahashi, Y Mase… - Nature …, 2019 - nature.com
G protein-gated inwardly rectifying potassium channel (GIRK) plays a key role in regulating
neurotransmission. GIRK is opened by the direct binding of the G protein βγ subunit (Gβγ) …
neurotransmission. GIRK is opened by the direct binding of the G protein βγ subunit (Gβγ) …