[图书][B] Molecular Surveillance and Drug Target Discovery for Human Filarial Nematodes

KJ Dahmer - 2023 - search.proquest.com
Vector-borne parasitic nematodes (roundworms) cause diseases associated with poverty
endemic to underdeveloped and exploited countries, infecting 100's of millions of people …

[HTML][HTML] Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization

N Hawryluk, L Zhiru, C Carlow, S Gokool… - International Journal for …, 2022 - Elsevier
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among
the most devastating of all tropical diseases, affecting over 86 million people worldwide. To …

The Host–Helminth Interface as a Rich Resource for Novel Drug Targets

TB Duguet, L Tritten - Human and Animal Filariases …, 2022 - Wiley Online Library
The evolutionary arms races underlying all host–helminth associations have resulted in
intricate negotiations enabling a successful infection. At the host–parasite interface, a …

Lessons from the genomes and transcriptomes of filarial nematodes

A Grote, S Lustigman, E Ghedin - Molecular and biochemical parasitology, 2017 - Elsevier
Human filarial infections are a leading cause of morbidity in the developing world. While a
small arsenal of drugs exists to treat these infections, there remains a tremendous need for …

Pharmacological profiling of a Brugia malayi muscarinic acetylcholine receptor as a putative antiparasitic target

KJ Gallo, NJ Wheeler, AM Elmi, PM Airs… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
The diversification of anthelmintic targets and mechanisms of action will help ensure the
sustainable control of nematode infections in response to the growing threat of drug …

Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus

J Adderley, T Wang, G Ma, Y Zheng, ND Young… - Parasites & …, 2022 - Springer
Background Gaining insight into molecular signalling pathways of socioeconomically
important parasitic nematodes has implications for understanding their molecular biology …

Exploitation of phylum-spanning omics resources reveals complexity in the nematode FLP signalling system and provides insights into flp-gene evolution

CJ McCoy, C Wray, L Freeman, BA Crooks, L Golinelli… - bioRxiv, 2024 - biorxiv.org
Background: Parasitic nematodes significantly undermine global human and animal health
and productivity. Parasite control is reliant on anthelmintic administration however over-use …

Perusal of parasitic nematode 'omics in the post-genomic era

JD Stoltzfus, AA Pilgrim, RH De'Broski - Molecular and biochemical …, 2017 - Elsevier
The advent of high-throughput, next-generation sequencing methods combined with
advances in computational biology and bioinformatics have greatly accelerated discovery …

RNAi-based discovery and validation of new drug targets in filarial nematodes

CA Behm, MM Bendig, JP McCarter, AE Sluder - Trends in parasitology, 2005 - cell.com
Human filarial nematodes cause river blindness and lymphatic filariasis, both of which are
diseases that produce considerable morbidity. Control of these diseases relies on drug …

[PDF][PDF] Biological insights into the parasitic nematode Heligmosomoides bakeri from bulk and single-cell transcriptomics

SMJ Pollo - 2023 - prism.ucalgary.ca
Heligmosomoides bakeri, a parasitic nematode (roundworm) of mice, is closely related to
economically important parasites of livestock and the hookworm parasites of humans. As a …