[图书][B] Molecular Surveillance and Drug Target Discovery for Human Filarial Nematodes
KJ Dahmer - 2023 - search.proquest.com
Vector-borne parasitic nematodes (roundworms) cause diseases associated with poverty
endemic to underdeveloped and exploited countries, infecting 100's of millions of people …
endemic to underdeveloped and exploited countries, infecting 100's of millions of people …
[HTML][HTML] Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization
N Hawryluk, L Zhiru, C Carlow, S Gokool… - International Journal for …, 2022 - Elsevier
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among
the most devastating of all tropical diseases, affecting over 86 million people worldwide. To …
the most devastating of all tropical diseases, affecting over 86 million people worldwide. To …
The Host–Helminth Interface as a Rich Resource for Novel Drug Targets
TB Duguet, L Tritten - Human and Animal Filariases …, 2022 - Wiley Online Library
The evolutionary arms races underlying all host–helminth associations have resulted in
intricate negotiations enabling a successful infection. At the host–parasite interface, a …
intricate negotiations enabling a successful infection. At the host–parasite interface, a …
Lessons from the genomes and transcriptomes of filarial nematodes
Human filarial infections are a leading cause of morbidity in the developing world. While a
small arsenal of drugs exists to treat these infections, there remains a tremendous need for …
small arsenal of drugs exists to treat these infections, there remains a tremendous need for …
Pharmacological profiling of a Brugia malayi muscarinic acetylcholine receptor as a putative antiparasitic target
The diversification of anthelmintic targets and mechanisms of action will help ensure the
sustainable control of nematode infections in response to the growing threat of drug …
sustainable control of nematode infections in response to the growing threat of drug …
Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus
Background Gaining insight into molecular signalling pathways of socioeconomically
important parasitic nematodes has implications for understanding their molecular biology …
important parasitic nematodes has implications for understanding their molecular biology …
Exploitation of phylum-spanning omics resources reveals complexity in the nematode FLP signalling system and provides insights into flp-gene evolution
CJ McCoy, C Wray, L Freeman, BA Crooks, L Golinelli… - bioRxiv, 2024 - biorxiv.org
Background: Parasitic nematodes significantly undermine global human and animal health
and productivity. Parasite control is reliant on anthelmintic administration however over-use …
and productivity. Parasite control is reliant on anthelmintic administration however over-use …
Perusal of parasitic nematode 'omics in the post-genomic era
JD Stoltzfus, AA Pilgrim, RH De'Broski - Molecular and biochemical …, 2017 - Elsevier
The advent of high-throughput, next-generation sequencing methods combined with
advances in computational biology and bioinformatics have greatly accelerated discovery …
advances in computational biology and bioinformatics have greatly accelerated discovery …
RNAi-based discovery and validation of new drug targets in filarial nematodes
CA Behm, MM Bendig, JP McCarter, AE Sluder - Trends in parasitology, 2005 - cell.com
Human filarial nematodes cause river blindness and lymphatic filariasis, both of which are
diseases that produce considerable morbidity. Control of these diseases relies on drug …
diseases that produce considerable morbidity. Control of these diseases relies on drug …
[PDF][PDF] Biological insights into the parasitic nematode Heligmosomoides bakeri from bulk and single-cell transcriptomics
SMJ Pollo - 2023 - prism.ucalgary.ca
Heligmosomoides bakeri, a parasitic nematode (roundworm) of mice, is closely related to
economically important parasites of livestock and the hookworm parasites of humans. As a …
economically important parasites of livestock and the hookworm parasites of humans. As a …