Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Zooming in and out of ferroptosis in human disease

X Wang, Y Zhou, J Min, F Wang - Frontiers of Medicine, 2023 - Springer
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

Targeting ferroptosis: new hope for as-yet-incurable diseases

M Conrad, SM Lorenz, B Proneth - Trends in molecular medicine, 2021 - cell.com
Attaining control over life and death decisions facilitates the identification of new therapeutic
strategies for diseases affected by early cell loss or resistance to cell death. In this context …

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

BR Stockwell - Cell, 2022 - cell.com
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Emerging mechanisms and disease implications of ferroptosis: potential applications of natural products

C Ge, S Zhang, H Mu, S Zheng, Z Tan… - Frontiers in Cell and …, 2022 - frontiersin.org
Ferroptosis, a newly discovered form of regulatory cell death (RCD), has been demonstrated
to be distinct from other types of RCD, such as apoptosis, necroptosis, and autophagy …

Ferroptosis: mechanisms, biology and role in disease

X Jiang, BR Stockwell, M Conrad - Nature reviews Molecular cell …, 2021 - nature.com
The research field of ferroptosis has seen exponential growth over the past few years, since
the term was coined in 2012. This unique modality of cell death, driven by iron-dependent …

Iron metabolism in ferroptosis

X Chen, C Yu, R Kang, D Tang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

Targeting ferroptosis: paving new roads for drug design and discovery

Y Gu, Y Li, J Wang, L Zhang, J Zhang… - European Journal of …, 2023 - Elsevier
Ferroptosis, first proposed in 2012, is an iron-dependent form of regulated cell death
characterized by excessive polyunsaturated fatty acid oxidation. In the past decade …

Ferroptosis detection: from approaches to applications

F Zeng, S Nijiati, L Tang, J Ye, Z Zhou… - Angewandte …, 2023 - Wiley Online Library
Understanding the intricate molecular machinery that governs ferroptosis and leveraging
this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and …

A roadmap to creating ferroptosis-based medicines

K Hadian, BR Stockwell - Nature chemical biology, 2021 - nature.com
Ferroptosis is a regulated form of non-apoptotic cell death implicated in pathological
settings. To be exploited clinically, ferroptosis requires reagents that unequivocally detect …