G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of …
M Sánchez-Soto, NM Boldizsar, KA Schardien… - Biomolecules, 2023 - mdpi.com
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to
regulate important physiological processes, such as movement, reward circuitry, emotion …
regulate important physiological processes, such as movement, reward circuitry, emotion …
G protein‐coupled receptor kinases regulate & [beta]‐arrestin interactions with the D2 dopamine receptor in an isoform‐specific manner and in the absence of direct …
NM Boldizsar, M Sanchez‐Soto, K Schardien… - The FASEB …, 2022 - Wiley Online Library
The D2 dopamine receptor (D2R) regulates numerous CNS functions including movement,
cognition, emotion, and reward circuitry. Agonist binding to the D2R promotes the activation …
cognition, emotion, and reward circuitry. Agonist binding to the D2R promotes the activation …
Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D1 Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and …
AE Moritz, NS Madaras, ML Rankin, LR Inbody… - International Journal of …, 2023 - mdpi.com
The D1 dopamine receptor (D1R) is a G protein-coupled receptor that signals through
activating adenylyl cyclase and raising intracellular cAMP levels. When activated, the D1R …
activating adenylyl cyclase and raising intracellular cAMP levels. When activated, the D1R …
The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation
TF Pack, MI Orlen, C Ray, SM Peterson… - Journal of Biological …, 2018 - ASBMB
The dopamine D2 receptor (D2R) is a G protein–coupled receptor (GPCR) that is critical for
many central nervous system functions. The D2R carries out these functions by signaling …
many central nervous system functions. The D2R carries out these functions by signaling …
Phosphorylation of the D1 Dopamine Receptor by G Protein‐Coupled Receptor Kinases: phosphorylation site identification and linkage to functional effects
A Moritz, M Rankin, L Inbody, R Free… - The FASEB …, 2021 - Wiley Online Library
Dopamine (DA) receptors (DARs) are G protein‐coupled receptors (GPCRs) that regulate
diverse physiological functions including movement, cognition, mood, and reward‐related …
diverse physiological functions including movement, cognition, mood, and reward‐related …
G Protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-β-arrestin complex: a case of …
In addition to its postsynaptic role, the dopamine D 3 receptor (D 3 R) serves as a
presynaptic autoreceptor, where it provides continuous feedback regulation of dopamine …
presynaptic autoreceptor, where it provides continuous feedback regulation of dopamine …
CRISPR/Cas9‐mediated knockout of G proteins and β‐arrestins delineates their distinct but interdependent roles in dopamine D1 receptor signaling
The dopamine D1 receptor (D1R) is a G protein‐coupled neurotransmitter receptor which
controls key brain functions including voluntary movement, memory, attention and reward …
controls key brain functions including voluntary movement, memory, attention and reward …
Ubiquitination of GRK2 is required for the β-arrestin-biased signaling pathway of dopamine D2 receptors to activate ERK kinases
H Liu, H Ma, X Zeng, C Wu, S Acharya… - International journal of …, 2023 - mdpi.com
A class-A GPCR dopamine D2 receptor (D2R) plays a critical role in the proper functioning
of neuronal circuits through the downstream activation of both G-protein-and β-arrestin …
of neuronal circuits through the downstream activation of both G-protein-and β-arrestin …
G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation
Y Namkung, C Dipace, E Urizar, JA Javitch… - Journal of Biological …, 2009 - ASBMB
We investigated the regulatory effects of GRK2 on D 2 dopamine receptor signaling and
found that this kinase inhibits both receptor expression and functional signaling in a …
found that this kinase inhibits both receptor expression and functional signaling in a …
G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor
We investigated the role of G protein-coupled receptor kinase (GRK)-mediated
phosphorylation in agonist-induced desensitization, arrestin association, endocytosis, and …
phosphorylation in agonist-induced desensitization, arrestin association, endocytosis, and …
相关搜索
- receptor kinase β arrestin
- receptor phosphorylation arrestin interactions
- β arrestins crispr cas9
- autoreceptor regulation β arrestin
- receptor kinases functional effects
- receptor kinase autoreceptor regulation
- signaling pathway β arrestin
- dopamine receptor β arrestin
- receptor phosphorylation β arrestin
- receptor kinases arrestin interactions
- dopamine receptor arrestin interactions
- erk kinases β arrestin
- dopamine receptor functional effects