Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice

A Parrish, M Boudaud, ET Grant, S Willieme… - Nature …, 2023 - nature.com
Alterations in the gut microbiome, including diet-driven changes, are linked to the rising
prevalence of food allergy. However, little is known about how specific gut bacteria trigger …

Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

E Ansaldo, LC Slayden, KL Ching, MA Koch, NK Wolf… - Science, 2019 - science.org
Intestinal adaptive immune responses influence host health, yet only a few intestinal
bacteria species that induce cognate adaptive immune responses during homeostasis have …

Commensal bacteria protect against food allergen sensitization

AT Stefka, T Feehley, P Tripathi, J Qiu… - Proceedings of the …, 2014 - National Acad Sciences
Environmentally induced alterations in the commensal microbiota have been implicated in
the increasing prevalence of food allergy. We show here that sensitization to a food allergen …

Interspecies commensal interactions have nonlinear impacts on host immunity

TA Rice, AA Bielecka, MT Nguyen, CE Rosen, D Song… - Cell host & …, 2022 - cell.com
The impacts of individual commensal microbes on immunity and disease can differ
dramatically depending on the surrounding microbial context; however, the specific bacterial …

Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila

M Derrien, P Van Baarlen, G Hooiveld, E Norin… - Frontiers in …, 2011 - frontiersin.org
Epithelial cells of the mammalian intestine are covered with a mucus layer that prevents
direct contact with intestinal microbes but also constitutes a substrate for mucus-degrading …

Microbiome and food allergy

AB Blázquez, MC Berin - Translational Research, 2017 - Elsevier
Food allergy is a common disease affecting approximately 8% of children and 5% of adults.
The prevalence has increased over the last two decades, suggesting an important …

Antibiotic-induced gut microbiota dysbiosis damages the intestinal barrier, increasing food allergy in adult mice

Q Zhang, L Cheng, J Wang, M Hao, H Che - Nutrients, 2021 - mdpi.com
(1) Background: The use of antibiotics affects the composition of gut microbiota. Studies
have suggested that the colonization of gut microbiota in early life is related to later food …

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

RL Greer, X Dong, ACF Moraes, RA Zielke… - Nature …, 2016 - nature.com
Cross-talk between the gut microbiota and the host immune system regulates host
metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut …

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

A Everard, C Belzer, L Geurts… - Proceedings of the …, 2013 - National Acad Sciences
Obesity and type 2 diabetes are characterized by altered gut microbiota, inflammation, and
gut barrier disruption. Microbial composition and the mechanisms of interaction with the host …

Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice

A Hänninen, R Toivonen, S Pöysti, C Belzer, H Plovier… - Gut, 2018 - gut.bmj.com
Objective Intestinal microbiota is implicated in the pathogenesis of autoimmune type 1
diabetes in humans and in non-obese diabetic (NOD) mice, but evidence on its causality …