Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer
M Hu, C Feng, Q Yuan, C Liu, B Ge, F Sun… - Nature …, 2023 - nature.com
Abstract mRNA delivery has shown high application value in the treatment of various
diseases, but its effective delivery is still a major challenge at present. Herein, we propose a …
diseases, but its effective delivery is still a major challenge at present. Herein, we propose a …
An RNA/DNA hybrid origami-based nanoplatform for efficient gene therapy
Nucleic acid nanostructures are promising biomaterials for the delivery of homologous gene
therapy drugs. Herein, we report a facile strategy for the construction of target mRNA …
therapy drugs. Herein, we report a facile strategy for the construction of target mRNA …
RNA origami nanostructures for potent and safe anticancer immunotherapy
Rapid developments in nucleic acid nanotechnology have enabled the rational design and
construction of self-assembling DNA and RNA nanostructures that are highly programmable …
construction of self-assembling DNA and RNA nanostructures that are highly programmable …
Efficient delivery of mRNA using crosslinked nucleic acid nanogel as a carrier
In vitro-transcribed messenger RNA (mRNA) can efficiently express the therapeutic proteins
in target cells without the concern of mutagenesis, which holds great promise for the …
in target cells without the concern of mutagenesis, which holds great promise for the …
Nanoscale platforms for messenger RNA delivery
Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic
applications in the past few years. A series of clinical trials are ongoing or will be initiated in …
applications in the past few years. A series of clinical trials are ongoing or will be initiated in …
Edge Length-Programmed Single-Stranded RNA Origami for Predictive Innate Immune Activation and Therapy
K Dai, Y Xu, Y Yang, J Shen, X Liu, X Tu… - Journal of the …, 2023 - ACS Publications
Ligands targeting nucleic acid-sensing receptors activate the innate immune system and
play a critical role in antiviral and antitumoral therapy. However, ligand design for in situ …
play a critical role in antiviral and antitumoral therapy. However, ligand design for in situ …
Integrated combination treatment using a “smart” chemotherapy and microRNA delivery system improves outcomes in an orthotopic colorectal cancer model
Mesoporous silica nanoparticles (MSN) can load and deliver potentially synergistic
anticancer agents such as small molecule cytotoxics (like doxorubicin, DOX) and nucleic …
anticancer agents such as small molecule cytotoxics (like doxorubicin, DOX) and nucleic …
RNA origami functions as a self-adjuvanted nanovaccine platform for cancer immunotherapy
Peptide-based vaccines have been widely investigated in cancer immunotherapy. Despite
their high specificity, safety, and low production cost, these vaccines have shown limited …
their high specificity, safety, and low production cost, these vaccines have shown limited …
Utilizing RNA origami scaffolds in Saccharomyces cerevisiae for dCas9-mediated transcriptional control
G Pothoulakis, MTA Nguyen… - Nucleic Acids …, 2022 - academic.oup.com
Designer RNA scaffolds constitute a promising tool for synthetic biology, as they can be
genetically expressed to perform specific functions in vivo such as scaffolding enzymatic …
genetically expressed to perform specific functions in vivo such as scaffolding enzymatic …
RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds
RNA origami is a framework for the modular design of nanoscaffolds that can be folded from
a single strand of RNA and used to organize molecular components with nanoscale …
a single strand of RNA and used to organize molecular components with nanoscale …