Abstract mRNA delivery has shown high application value in the treatment of various
diseases, but its effective delivery is still a major challenge at present. Herein, we propose a …

Nucleic acid nanostructures are promising biomaterials for the delivery of homologous gene
therapy drugs. Herein, we report a facile strategy for the construction of target mRNA …

Rapid developments in nucleic acid nanotechnology have enabled the rational design and
construction of self-assembling DNA and RNA nanostructures that are highly programmable …

In vitro-transcribed messenger RNA (mRNA) can efficiently express the therapeutic proteins
in target cells without the concern of mutagenesis, which holds great promise for the …

Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic
applications in the past few years. A series of clinical trials are ongoing or will be initiated in …

Ligands targeting nucleic acid-sensing receptors activate the innate immune system and
play a critical role in antiviral and antitumoral therapy. However, ligand design for in situ …

Mesoporous silica nanoparticles (MSN) can load and deliver potentially synergistic
anticancer agents such as small molecule cytotoxics (like doxorubicin, DOX) and nucleic …

Peptide-based vaccines have been widely investigated in cancer immunotherapy. Despite
their high specificity, safety, and low production cost, these vaccines have shown limited …

Designer RNA scaffolds constitute a promising tool for synthetic biology, as they can be
genetically expressed to perform specific functions in vivo such as scaffolding enzymatic …

RNA origami is a framework for the modular design of nanoscaffolds that can be folded from
a single strand of RNA and used to organize molecular components with nanoscale …