[HTML][HTML] Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic
Antibiotics that have multiple cellular targets theoretically reduce the frequency of resistance
evolution, but adaptive trajectories and resistance mechanisms against such antibiotics are …
evolution, but adaptive trajectories and resistance mechanisms against such antibiotics are …
[HTML][HTML] Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates
The rise of antibiotic resistance in many bacterial pathogens has been driven by the spread
of a few successful strains, suggesting that some bacteria are genetically pre-disposed to …
of a few successful strains, suggesting that some bacteria are genetically pre-disposed to …
[HTML][HTML] Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance
Background Antibiotic resistance is a major problem for human health. Multidrug resistance
efflux pumps, especially those of the Resistance-Nodulation-Cell Division (RND) family, are …
efflux pumps, especially those of the Resistance-Nodulation-Cell Division (RND) family, are …
[HTML][HTML] The role of efflux pumps in the transition from low-level to clinical antibiotic resistance
Antibiotic resistance is on the rise and has become one of the biggest public health
challenges of our time. Bacteria are able to adapt to the selective pressure exerted by …
challenges of our time. Bacteria are able to adapt to the selective pressure exerted by …
[HTML][HTML] Antimicrobial resistance and virulence common mechanisms
E Giraud, I Rychlik, A Cloeckaert - Frontiers in microbiology, 2017 - frontiersin.org
Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the
spread of clones combining multiple antibiotic resistance and a high virulence level is an …
spread of clones combining multiple antibiotic resistance and a high virulence level is an …
[HTML][HTML] Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains
Background Efflux pumps mediate antimicrobial resistance in several WHO critical priority
bacterial pathogens. However, most available data come from laboratory strains. The …
bacterial pathogens. However, most available data come from laboratory strains. The …
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
Antibiotic resistance can evolve through the sequential accumulation of multiple mutations.
To study such gradual evolution, we developed a selection device, the'morbidostat', that …
To study such gradual evolution, we developed a selection device, the'morbidostat', that …
[HTML][HTML] Mutators can drive the evolution of multi-resistance to antibiotics
Antibiotic combination therapies are an approach used to counter the evolution of
resistance; their purported benefit is they can stop the successive emergence of …
resistance; their purported benefit is they can stop the successive emergence of …
Conserved Evolutionary Trajectory Can Be Perturbed to Prevent Resistance Evolution under Norfloxacin Pressure by Forcing Mycobacterium smegmatis on Alternate …
Akanksha, S Mehra - ACS Infectious Diseases, 2024 - ACS Publications
Antibiotic resistance is a pressing health issue, with the emergence of resistance in bacteria
outcompeting the discovery of novel drug candidates. While many studies have used …
outcompeting the discovery of novel drug candidates. While many studies have used …
Targets for combating the evolution of acquired antibiotic resistance
Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics.
Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves …
Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves …