Glaucoma: neuroprotection with NAD-based therapeutic interventions

A Chiarugi - Trends in Pharmacological Sciences, 2023 - cell.com
Clinical evidence shows that intraocular hypertension is not the primary pathogenetic event
of glaucoma, whereas early neurodegeneration of retinal ganglion cells (RGCs) represents …

Systemic treatment with nicotinamide riboside is protective in two mouse models of retinal ganglion cell damage

X Zhang, N Zhang, MA Chrenek, PE Girardot, J Wang… - Pharmaceutics, 2021 - mdpi.com
Glaucoma etiology often includes retinal ganglion cell (RGC) death associated with elevated
intraocular pressure (IOP). However, even when IOP is managed well, disease can …

Neuroprotection in glaucoma: drug-based approaches

W Cheung, L Guo, MF Cordeiro - Optometry and Vision Science, 2008 - journals.lww.com
In recent years the focus of glaucoma research has shifted toward neuroprotection, as the
traditional strategies of lowering intraocular pressure have been shown to be unable to …

[HTML][HTML] Neuroprotective strategies in glaucoma-translation to clinical trials

CEH Fang, L Guo, D Hill, TE Yap, MF Cordeiro - OBM Neurobiology, 2020 - lidsen.com
Neuroprotection in glaucoma is any medical treatment by which decline in visual function
can be slowed or prevented by supporting the health and survival of neural cells …

Neuroprotective strategies in glaucoma

CA Gossman, J Christie, MK Webster… - Current …, 2016 - ingentaconnect.com
Background: Glaucoma is characterized as a neuropathic disease that causes progressive
degeneration of retinal ganglion cells (RGCs) in the retina, resulting in irreversible loss of …

Neuroprotective agents in the management of glaucoma

C Nucci, A Martucci, C Giannini, LA Morrone, G Bagetta… - Eye, 2018 - nature.com
Glaucoma is an optic neuropathy, specifically a neurodegenerative disease characterized
by loss of retinal ganglion cells (RGCs) and their axons. The pathogenesis of RGC loss in …

Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects

A Boccaccini, D Cavaterra, C Carnevale… - Molecular Aspects of …, 2023 - Elsevier
In the last years, neuroprotective therapies have attracted the researcher interests as
modern and challenging approach for the treatment of neurodegenerative diseases, aimed …

Current perspective of neuroprotection and glaucoma

K Tian, S Shibata-Germanos, M Pahlitzsch… - Clinical …, 2015 - Taylor & Francis
Glaucoma is the second leading cause of blindness worldwide and is most notably
characterized by progressive optic nerve atrophy and advancing loss of retinal ganglion …

Rationale for the use of multifunctional drugs as neuroprotective agents for glaucoma☆

J Fang, F Jiang, J Li, Y Zhu - Neural Regeneration Research, 2012 - journals.lww.com
Glaucoma, the leading cause globally of irreversible blindness, is a neurodegenerative
disease characterized by progressive retinal ganglion cell death. To date, no drug has been …

Targets of neuroprotection in glaucoma

S He, DL Stankowska, DZ Ellis… - Journal of Ocular …, 2018 - liebertpub.com
Progressive neurodegeneration of the optic nerve and the loss of retinal ganglion cells is a
hallmark of glaucoma, the leading cause of irreversible blindness worldwide, with primary …