[HTML][HTML] Prognostic Usefulness of Motor Unit Number Index (MUNIX) in Patients Newly Diagnosed with Amyotrophic Lateral Sclerosis

B Risi, S Cotti Piccinelli, S Gazzina, B Labella… - Journal of Clinical …, 2023 - mdpi.com
The MUNIX technique allows us to estimate the number and size of surviving motor units
(MUs). Previous studies on ALS found correlations between MUNIX and several clinical …

Could the motor unit number index be an early prognostic biomarker for amyotrophic lateral sclerosis?

AM Grapperon, V Harlay, M Boucekine, D Devos… - Clinical …, 2024 - Elsevier
Objective To evaluate the associations between motor unit number index (MUNIX) and
disease progression and prognosis in amyotrophic lateral sclerosis (ALS) in a large-scale …

Lower motor neuron involvement in ALS assessed by motor unit number index (MUNIX): Long-term changes and reproducibility

D Fathi, B Mohammadi, R Dengler, S Böselt… - Clinical …, 2016 - Elsevier
Objective Motor unit number estimation (MUNE) techniques such as motor unit number
index (MUNIX) have been used to quantify lower motor neuron loss and disease …

Tracking motor neuron loss in a set of six muscles in amyotrophic lateral sclerosis using the Motor Unit Number Index (MUNIX): a 15-month longitudinal multicentre …

C Neuwirth, PE Barkhaus, C Burkhardt… - Journal of Neurology …, 2015 - jnnp.bmj.com
Background Motor Unit Number Index (MUNIX) is a novel neurophysiological measure that
provides an index of the number of functional lower motor neurons in a given muscle. So far …

[HTML][HTML] Motor unit number index (MUNIX) in the D50 disease progression model reflects disease accumulation independently of disease aggressiveness in ALS

T Ebersbach, A Roediger, R Steinbach… - Scientific Reports, 2022 - nature.com
The neurophysiological technique motor unit number index (MUNIX) is increasingly used in
clinical trials to measure loss of motor units. However, the heterogeneous disease course in …

Motor Unit Number Index (MUNIX) detects motor neuron loss in pre-symptomatic muscles in Amyotrophic Lateral Sclerosis

C Neuwirth, PE Barkhaus, C Burkhardt, J Castro… - Clinical …, 2017 - Elsevier
Abstract Objective Motor Unit Number Index (MUNIX) is a quantitative neurophysiological
measure that provides an index of the number of lower motor neurons supplying a muscle. It …

[HTML][HTML] Multipoint incremental motor unit number estimation versus amyotrophic lateral sclerosis functional rating scale and the medical research council sum score …

SA Jagtap, A Kuruvilla, P Govind, MD Nair… - Annals of Indian …, 2014 - journals.lww.com
Objective: The objective of the present study is to evaluate the rate of progression in ALS
using multipoint incremental MUNE and to compare MUNE, ALSFRS and MRC sum score at …

Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis

ML Escorcio‐Bezerra, A Abrahao, KF Nunes… - Muscle & …, 2018 - Wiley Online Library
Introduction: Our objective was to determine the utility of motor unit number index (MUNIX)
and neurophysiological index (NI) as surrogate biomarkers of disease progression in limbs …

Motor unit number index (MUNIX): a novel neurophysiological technique to follow disease progression in amyotrophic lateral sclerosis

C Neuwirth, S Nandedkar, E StåLberg… - Muscle & nerve, 2010 - Wiley Online Library
Motor unit number estimation techniques in amyotrophic lateral sclerosis (ALS) patients are
technically challenging and time‐consuming. The Motor Unit Number Index (MUNIX) is a …

Intra-rater reliability of motor unit number estimation and quantitative motor unit analysis in subjects with amyotrophic lateral sclerosis

CT Ives, TJ Doherty - Clinical Neurophysiology, 2014 - Elsevier
Objectives To assess the intra-rater reliability of decomposition-enhanced spike-triggered
averaging (DE-STA) motor unit number estimation (MUNE) and quantitative motor unit …