Objective Acute exacerbations of biofilm-associated Pseudomonas aeruginosa infections in
cystic fibrosis (CF) have limited treatment options. Ceftolozane/tazobactam (alone and with a …

Acute exacerbations of chronic respiratory infections in patients with cystic fibrosis are highly
challenging due to hypermutable Pseudomonas aeruginosa, biofilm formation and …

Abstract Objective Hypermutable Pseudomonas aeruginosa strains are highly prevalent in
chronic lung infections of patients with cystic fibrosis (CF). Acute exacerbations of these …

Pseudomonas aeruginosa colonisation and chronic lung infection associated with biofilm
formation is a major cause of morbidity and mortality in cystic fibrosis (CF) patients. There is …

Treatment of exacerbations of chronic Pseudomonas aeruginosa infections in patients with
cystic fibrosis (CF) is highly challenging due to hypermutability, biofilm formation, and an …

OBJECTIVES: The conventional in vitro models simulate pharmacodynamics of antibiotics in
the treatment of planktonic Pseudomonas aeruginosa. In this study, we propose a novel …

Objectives Ceftolozane/tazobactam is a potential tool for infections caused by multidrug-
resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa), but its efficacy against some …

Pseudomonas aeruginosa causes a variety of life-threatening infections, some of which are
associated with planktonic and others with biofilm states. Herein, we tested the combination …

Traditional therapeutic strategies to control chronic colonization in cystic fibrosis (CF)
patients are based on the use of a single nebulized antibiotic. In this study, we evaluated the …

The prognosis of patients with cystic fibrosis (CF) has improved dramatically over the last
three decades although the majority of patients still die in early adulthood. Infection with …