Protein translation is tightly and precisely controlled by multiple mechanisms including
upstream open reading frames (uORFs), but the origins of uORFs and their role in maize are …

Transposons are major drivers of mammalian genome evolution. To obtain new insights into
the contribution of transposons to the regulation of protein translation, we here examined …

Upstream open reading frames (uORFs) play widespread regulatory functions in modulating
mRNA translation in eukaryotes, but the principles underlying the genomic distribution and …

Insertion of transposed elements within mammalian genes is thought to be an important
contributor to mammalian evolution and speciation. Insertion of transposed elements into …

Abstract Background Transposable elements (TEs) have significantly influenced the
evolution of transcriptional regulatory networks in the human genome. Post-transcriptional …

So far, the annotation of translation initiation sites (TISs) has been based mostly upon
bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to …

Upstream open reading frames (uORFs), located in transcript leaders (5′ UTRs), are potent
cis-acting regulators of translation and mRNA turnover. Recent genome-wide ribosome …

There are∼ 650,000 Alu elements in transcribed regions of the human genome. These
elements contain cryptic splice sites, so they are in constant danger of aberrant …

Structural differences between genomes are a major source of genetic variation that
contributes to phenotypic differences. Transposable elements, mobile genetic sequences …

Identifying open reading frames (ORFs) being translated is not a trivial task. ProTInSeq is a
technique designed to characterize proteomes by sequencing transposon insertions …