Keratinocyte senescence contributes to skin ageing and epidermal dysfunction. According to
the existing knowledge, the transcription factor ΔNp63α plays pivotal roles in differentiation …

p63 is critical for squamous epithelial development, and elevated levels of the ΔNp63α
isoform are seen in squamous cell cancers of various organ sites. However, significant …

The p63 transcription factor is critical for epidermis formation in embryonic development, but
its role in the adult epidermis is poorly understood. In this study, we show that acute genetic …

Skin keratinocytes form a tightly knit and layered epithelium at the surface of the body
protecting the body from the outside environment. The formation and maintenance of skin …

Background p63 is a transcription factor that plays an important role in skin epidermal
development and differentiation. The p63 gene encodes for two major protein isoforms …

In this study we show that ΔNp63α overexpression in primary human epidermal
keratinocytes causes decreased cell proliferation and increased apoptosis. These changes …

Unlike its family member p53, TP63 is rarely mutated in human cancer. However, ΔNp63α
protein levels are often elevated in tumors of epithelial origin, such as squamous cell …

A dominant negative form of p63, ΔNp63α, is critical for maintaining the proliferative
potential of epidermal stem cells and progenitor cells. The expression of ΔNp63α also …

The p53 protein plays a pivotal role in determining the quality of the response to DNA
damage through its transcriptional activity. Upon DNA damage, p53 is activated by post …

ΔNp63 is overexpressed in squamous carcinomas where it is associated with proliferation
and is believed to enhance cell growth by blocking p53-mediated transactivation. In normal …