Integrative human atrial modelling unravels interactive protein kinase A and Ca2+/calmodulin-dependent protein kinase II signalling as key determinants of atrial …
Aims Atrial fibrillation (AF), the most prevalent clinical arrhythmia, is associated with atrial
remodelling manifesting as acute and chronic alterations in expression, function, and …
remodelling manifesting as acute and chronic alterations in expression, function, and …
Integrative human atrial modeling unravels interactive PKA and CaMKII signaling as key determinant of atrial arrhythmogenesis
Atrial fibrillation (AF), the most prevalent clinical arrhythmia, is associated with atrial
remodeling manifesting as acute and chronic alterations in expression, function, and …
remodeling manifesting as acute and chronic alterations in expression, function, and …
[HTML][HTML] In Silico Screening of the Key Cellular Remodeling Targets in Chronic Atrial Fibrillation
JT Koivumäki, G Seemann… - PLoS computational …, 2014 - journals.plos.org
Chronic atrial fibrillation (AF) is a complex disease with underlying changes in
electrophysiology, calcium signaling and the structure of atrial myocytes. How these …
electrophysiology, calcium signaling and the structure of atrial myocytes. How these …
[HTML][HTML] Atrial fibrillation: Insights from animal models, computational modeling, and clinical studies
C Yamamoto, NA Trayanova - EBioMedicine, 2022 - thelancet.com
Atrial fibrillation (AF) is the most common human arrhythmia, affecting millions of patients
worldwide. A combination of risk factors and comorbidities results in complex atrial …
worldwide. A combination of risk factors and comorbidities results in complex atrial …
[HTML][HTML] Computational modeling of electrophysiology and pharmacotherapy of atrial fibrillation: recent advances and future challenges
M Vagos, IGM van Herck, J Sundnes… - Frontiers in …, 2018 - frontiersin.org
The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …
Computational modeling: What does it tell us about atrial fibrillation therapy?
Atrial fibrillation (AF) is a complex cardiac arrhythmia with diverse etiology that negatively
affects morbidity and mortality of millions of patients. Technological and experimental …
affects morbidity and mortality of millions of patients. Technological and experimental …
Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study
By sensing changes in intracellular Ca2+, small-conductance Ca2+-activated K+ (SK)
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …
Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation
The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …
ion channels, transporters and signalling pathways to cardiac electrophysiology …
[引用][C] Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation: what can we learn from computer models?
Atrial fibrillation (AF) remains a major clinical problem (Nattel et al., 2021). Conceptually, AF
requires a trigger, often in the form of ectopic (triggered) activity, and a vulnerable substrate …
requires a trigger, often in the form of ectopic (triggered) activity, and a vulnerable substrate …
[HTML][HTML] Excitation-Contraction Coupling, Electrophysiology, and Arrhythmias: Dual effects of the small-conductance Ca2+-activated K+ current on human atrial …
NT Herrera, X Zhang, H Ni, MM Maleckar… - American Journal of …, 2023 - ncbi.nlm.nih.gov
By sensing changes in intracellular Ca 2+, small-conductance Ca 2+-activated K+(SK)
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …
channels dynamically regulate the dynamics of the cardiac action potential (AP) on a beat-to …