Compelling epidemiological and animal experimental data demonstrate that
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …

Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

The placenta is a transient organ found in eutherian mammals that evolved primarily to
provide nutrients for the developing fetus. The placenta exchanges a wide array of nutrients …

Robust evidence of fetal programming of adult disease has surfaced in the last several
decades. Human and preclinical investigations of intrauterine insults report perturbations in …

Adverse maternal environments such as small size, malnutrition, and metabolic conditions
are known to influence fetal growth outcomes. Similarly, fetal growth and metabolic …

The placental exposome represents the sum of all placental exposures, and through its
influence on placental function can affect an individual's susceptibility to cardio-metabolic …

Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

Adverse influences during fetal life alter the structure and function of distinct cells, organ
systems or homoeostatic pathways, thereby 'programming'the individual for an increased …

The intrauterine environment has an important influence on lifelong health, and babies who
grew poorly in the womb are more likely to develop chronic diseases in later life. Placental …

Background During development, the placenta can be said to be the most important organ,
however, the most poorly researched. There is currently a broader understanding of how …