The role of glia, particularly astrocytes, in mediating the central nervous system's response
to injury and neurodegenerative disease is an increasingly well studied topic. These cells …

Astrocytes serve multiple roles in helping to maintain homeostatic physiology of central
nervous system tissue, ranging from metabolic support to coupling between vascular and …

Astroyctes serve myriad functions but are especially critical in white matter tracts, where
energy-demanding axons propagate action potentials great distances between neurons …

Background The optic nerve is an important tissue in glaucoma and the unmyelinated nerve
head region remains an important site of many early neurodegenerative changes. In both …

Glaucoma causes loss of vision through degeneration of the retinal ganglion cell (RGC)
projection to the brain. The disease is characterized by sensitivity to intraocular pressure …

Neuroinflammation relying on the inflammatory responses of glial cells has emerged as an
impactful component of the multifactorial etiology of neurodegeneration in glaucoma. It has …

Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic
nerve head where they contribute critically to extracellular matrix synthesis during …

The optic nerve head is thought to be the site of initial injury to retinal ganglion cell injury in
glaucoma. In the initial segment of the optic nerve directly behind the globe, the ganglion …

Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells
(RGCs) in the retina, often as a result of prolonged increases in intraocular pressure. We …

Glaucoma, a neurodegenerative disease affecting retinal ganglion cells (RGC), is a leading
cause of blindness. Since gliosis is common in neurodegenerative disorders, it is important …