[HTML][HTML] Retinal ganglion cells adapt to ionic stress in experimental glaucoma
Introduction Identification of early adaptive and maladaptive neuronal stress responses is an
important step in developing targeted neuroprotective therapies for degenerative disease. In …
important step in developing targeted neuroprotective therapies for degenerative disease. In …
Mild intraocular pressure elevation in mice reveals distinct retinal ganglion cell functional thresholds and pressure-dependent properties
X Tao, J Sabharwal, RL Seilheimer, SM Wu… - Journal of …, 2019 - Soc Neuroscience
Elevation of intraocular pressure (IOP) causes retinal ganglion cell (RGC) dysfunction and
death and is a major risk factor for glaucoma. We used a bead injection technique to …
death and is a major risk factor for glaucoma. We used a bead injection technique to …
Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma
Diseases of the brain involve early axon dysfunction that often precedes outright
degeneration. Pruning of dendrites and their synapses represents a potential driver of …
degeneration. Pruning of dendrites and their synapses represents a potential driver of …
Adaptive responses to neurodegenerative stress in glaucoma
DJ Calkins - Progress in retinal and eye research, 2021 - Elsevier
Glaucoma causes loss of vision through degeneration of the retinal ganglion cell (RGC)
projection to the brain. The disease is characterized by sensitivity to intraocular pressure …
projection to the brain. The disease is characterized by sensitivity to intraocular pressure …
Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma
L Della Santina, DM Inman, CB Lupien… - Journal of …, 2013 - Soc Neuroscience
Intraocular pressure (IOP) elevation is a principal risk factor for glaucoma. Using a
microbead injection technique to chronically raise IOP for 15 or 30 d in mice, we identified …
microbead injection technique to chronically raise IOP for 15 or 30 d in mice, we identified …
Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy
Glaucoma is a complex neurodegenerative disorder that is expected to affect 80 million
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …
people by the end of this decade. Retinal ganglion cells (RGCs) are the most affected cell …
[HTML][HTML] CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of …
Background Glaucoma is a leading neurodegenerative disease affecting over 70 million
individuals worldwide. Early pathological events of axonal degeneration and retinopathy in …
individuals worldwide. Early pathological events of axonal degeneration and retinopathy in …
[HTML][HTML] Mechanisms of retinal ganglion cell injury following acute increases in intraocular pressure
The maintenance of intraocular pressure (IOP) is critical to preserving the pristine optics
required for vision. Disturbances in IOP can directly impact the optic nerve and retina, and …
required for vision. Disturbances in IOP can directly impact the optic nerve and retina, and …
Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement
EE Chang, JL Goldberg - Ophthalmology, 2012 - Elsevier
Glaucoma is a progressive neurodegenerative disease of retinal ganglion cells (RGCs)
associated with characteristic axon degeneration in the optic nerve. Clinically, our only …
associated with characteristic axon degeneration in the optic nerve. Clinically, our only …
[HTML][HTML] An in vitro pressure model towards studying the response of primary retinal ganglion cells to elevated hydrostatic pressures
Glaucoma is a leading cause of blindness characterized by progressive degeneration of
retinal ganglion cells (RGCs). A well-established risk factor for the development and …
retinal ganglion cells (RGCs). A well-established risk factor for the development and …