Therapeutic reprogramming of bone marrow derived mesenchymal stem cells during influenza infection is mediated by type I interferon signaling and interleukin 11

MM Barroso - 2023 - jlupub.ub.uni-giessen.de
Mesenchymal stem cells (MSC) show promising therapeutic potential in different forms of
acute lung injury. However, it is not clear how MSC sense injury during viral lung infections …

Influenza-infected Alveolar Epithelial Cell Have Increased Resilience After Bone-Marrow-Derived Mesenchymal Stem Cell Therapeutic Delivery, Via Type I Interferon …

MM Barroso, AI Vazquez-Armendariz… - … AND COVID-19 …, 2024 - atsjournals.org
Rationale: Bone marrow-derived mesenchymal stem cells (BM-MSC) show promising
therapeutic potential, but it is unclear how they act upon viral lung infections. The aim of this …

Mesenchymal stem cell plasticity and therapeutic programming in acute lung injury

MM Barroso, AI Vazquez, L Jankauskaite… - C107. Going viral to …, 2019 - atsjournals.org
Rationale: Following influenza virus (IV)-induced injury, the initiation of well-coordinated
programs for inflammation termination and alveolar epithelium regeneration are necessary …

LSC Abstract–Murine bone marrow-derived mesenchymal stem cells exert anti-viral and barrier-protective properties in influenza virus infection

L Jankauskaite, C Schmoldt, J Lohmeyer, S Herold - 2015 - Eur Respiratory Soc
Influenza virus (IV) infects the upper respiratory tract and occasionally spreads to the
alveolar compartment causing primary IV pneumonia. This frequently progresses to acute …

Therapeutic potential of murine bone marrow derived mesenchymal stem cells in influenza virus-induced pneumonia

L Jankauskaite, C Schmoldt, J Lohmeyer… - …, 2014 - thieme-connect.com
Influenza virus (IV) infects the human upper respiratory tract and occasionally spreads to the
alveolar compartment causing primary pneumonia. This can lead to acute respiratory …

[HTML][HTML] Mesenchymal stem cells induce dynamic immunomodulation of airway and systemic immune cells in vivo but do not improve survival for mice with H1N1 …

Y Tan, Y Wang, L Souza-Moreira, C Wang… - … in Bioengineering and …, 2023 - frontiersin.org
Introduction: Influenza A virus (IAV)-induced acute lung injury (ALI) is characterized by
pronounced proinflammatory activation and respiratory lung dysfunction. In this study, we …

[HTML][HTML] Functional phenotype and role of resident and recruited bone marrow derived exudate macrophages in influenza virus-induced lung injury and repair

B Selvakumar, J Wilhelm, D Wolff, W Seeger… - International Journal of …, 2018 - ijidonline.com
Background: Alveolar macrophages (AM) play an important role in host defense and tissue
homeostasis. Even though macrophage polarization has been extensively studied in …

Therapeutic implications of human umbilical cord mesenchymal stromal cells in attenuating influenza A (H5N1) virus–associated acute lung injury

H Loy, DIT Kuok, KPY Hui, MHL Choi… - The Journal of …, 2019 - academic.oup.com
Background Highly pathogenic avian influenza viruses can cause severe forms of acute
lung injury (ALI) in humans, where pulmonary flooding leads to respiratory failure. The …

GM-CSF drives alveolar regeneration from distal lung stem cell pools after influenza virus infection

AI Vazquez, M Heiner, E El Agha, S Bellusci… - A96. THE STEM AND …, 2018 - atsjournals.org
Rationale: Severe influenza virus (IAV) pneumonia is characterized by extensive epithelial
cell death, edema, and inflammation causing acute lung injury. In order to regain …

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo

MCW Chan, DIT Kuok, CYH Leung… - Proceedings of the …, 2016 - National Acad Sciences
Influenza can cause acute lung injury. Because immune responses often play a role,
antivirals may not ensure a successful outcome. To identify pathogenic mechanisms and …