Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational
acquisition of antibiotic resistance (AR). However, AR can be temporally induced, and the …

Collateral sensitivity is an evolutionary trade-off whereby acquisition of the adaptive
phenotype of resistance to an antibiotic leads to the nonadaptive increased susceptibility to …

The analysis of trade-offs, as collateral sensitivity, associated with the acquisition of
antibiotic resistance, is mainly based on the use of model strains. However, the possibility of …

There is urgent need to develop novel treatment strategies to reduce antimicrobial
resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases …

When bacteria evolve resistance against a particular antibiotic, they may simultaneously
gain increased sensitivity against a second one. Such collateral sensitivity may be exploited …

The rise of antibiotic resistance and the reduced amount of novel antibiotics support the
need of developing novel strategies to fight infections, based on improving the use of the …

Pseudomonas aeruginosa has an extraordinary capacity to evade the activity of antibiotics
through a complex interplay of intrinsic and mutation-driven resistance pathways, which are …

Evolution is at the core of the impending antibiotic crisis. Sustainable therapy must thus
account for the adaptive potential of pathogens. One option is to exploit evolutionary trade …

To tackle the global antibiotic resistance crisis, antibiotic resistance acquired either vertically
by chromosomal mutations or horizontally through antibiotic resistance genes (ARGs) have …

Evolved resistance to one antibiotic may be associated with" collateral" sensitivity to other
drugs. Here, we provide an extensive quantitative characterization of collateral effects in …