Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an impairment of
cognition and memory. Current research on connectomics have now related changes in the …

With the increasing prevalence of Alzheimer's disease (AD) among aging populations and
the limited therapeutic options available to slow or reverse its progression, the need has …

Tau neurofibrillary tangles, a pathophysiological hallmark of Alzheimer's disease (AD),
exhibit a stereotypical spatiotemporal trajectory that is strongly correlated with disease …

The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

In Alzheimer's disease (AD), the Braak staging scheme suggests a stereotypical tau
spreading pattern that does, however, not capture interindividual variability in tau deposition …

Tau tangles are a pathological hallmark of Alzheimer's disease (AD) with strong correlations
existing between tau aggregation and cognitive decline. Studies in mouse models have …

Background: Alzheimer's disease involves widespread and progressive deposition of
misfolded protein tau (τ), first appearing in the entorhinal cortex, coagulating in longer …

Neuropathological staging studies have suggested that tau pathology spreads through the
brain in Alzheimer's disease (AD) and other tauopathies, but it is unclear how …

Background: Graph theory and connectomics are new techniques for uncovering disease-
induced changes in the brain's structural network. Most prior studied have focused on …

Tau tangles in the brain cortex spread along the brain network in distinct patterns among
Alzheimer's patients. We aim to simulate their network-based spreading within the cortex …