The involvement of p53 aggregation in cancer pathogenesis emphasizes the importance of
unraveling the mechanisms underlying mutation-induced p53 destabilization. And …

Background: Bone metastasis (BM) seriously affects the quality of life and reduces the
survival time of patients with non-small-cell lung cancer (NSCLC). The genomic …

Abstract According to the International Agency for Research on Cancer, leukemia ranks 14
th in incidence and 11 th in mortality and has a 5-year prevalence of approximately …

Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not
only in loss of its tumor-suppressive function but also acquisition of dominant-negative and …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants formed during the
incomplete combustion of organic matter such as tobacco. Among these, benzo [a] pyrene …

Simple Summary This study investigated a new blood test (9G testTM Cancer/Lung) for early
lung cancer detection. This test measures complexes of autoantibodies with specific lung …

Background Squamous cell carcinoma (SCC) of the dorsum of the tongue is extremely rare,
and it clinically resembles various benign lesions. Somatic mutations in TP53 and some …

The tumor suppressor p53 is a transcription factor with a powerful antitumor activity that is
controlled by its negative regulator murine double minute 2 (MDM2, also termed HDM2 in …

Germline (GL) predisposition to acute myeloid leukemia (AML) has been established as an
independent disease entity in the latest World Health Organization classification. Following …

Abstract Purpose Li-Fraumeni Syndrome (LFS) is a rare cancer predisposing condition
caused by germline pathogenic TP53 variants, in which core tumors comprise sarcomas …