The role of SARS-CoV-2-mediated NF-κB activation in COVID-19 patients
Q Zhou, L Zhang, Y Dong, Y Wang, B Zhang… - Hypertension …, 2024 - nature.com
Abstract The SARS-CoV-2 pandemic, now in its third year, has had a profound impact on
public health and economics all over the world. Different populations showed varied …
public health and economics all over the world. Different populations showed varied …
A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID …
MI Prasanth, DL Wannigama, AM Reiersen… - Scientific Reports, 2024 - nature.com
Abstract There have been 774,075,242 cases of COVID-19 and 7,012,986 deaths worldwide
as of January 2024. In the early stages of the pandemic, there was an urgent need to reduce …
as of January 2024. In the early stages of the pandemic, there was an urgent need to reduce …
Navigating the complexities of drug development for inflammatory bowel disease
Inflammatory bowel disease (IBD)—consisting of ulcerative colitis and Crohn's disease—is a
complex, heterogeneous, immune-mediated inflammatory condition with a multifactorial …
complex, heterogeneous, immune-mediated inflammatory condition with a multifactorial …
Antiviral efficacy of fluoxetine in early symptomatic COVID-19: An open-label, randomised, controlled, adaptive platform trial (PLATCOV)
P Jittamala, S Boyd, WHK Schilling, JA Watson… - medRxiv, 2024 - medrxiv.org
Background The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine
were repurposed for the treatment of early COVID-19 based on their antiviral activity in vitro …
were repurposed for the treatment of early COVID-19 based on their antiviral activity in vitro …
Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19
G Zeng, J Li, L Wang, Z Zhang - Molecular Psychiatry, 2024 - nature.com
We have read with great interest the study by de Kirenga et al., about efficacy and safety of
fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 [1] …
fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 [1] …
Applying lessons of COVID-19 and other emerging infectious diseases to future outbreaks
Infectious diseases are emerging and re-emerging far more frequently than many
appreciate. In the past two decades alone, there have been numerous outbreaks (eg, Ebola …
appreciate. In the past two decades alone, there have been numerous outbreaks (eg, Ebola …
Exploring the causal effects of depression and antidepressants on COVID-19
L Fu, A Baranova, H Cao, F Zhang - Journal of Affective Disorders, 2024 - Elsevier
Background While existing studies have suggested an increased risk of COVID-19 in
patients with depression, the causal impact of MDD on the severity of COVID-19 remains to …
patients with depression, the causal impact of MDD on the severity of COVID-19 remains to …
Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants
L Thümmler, N Beckmann, C Sehl, M Soddemann… - Viruses, 2024 - mdpi.com
The pandemic caused by SARS-CoV-2 is still a major health problem. Newly emerging
variants and long-COVID-19 represent a challenge for the global health system. In …
variants and long-COVID-19 represent a challenge for the global health system. In …
Fluvoxamine inhibits Th1 and Th17 polarization and function by repressing glycolysis to attenuate autoimmune progression in type 1 diabetes
Y Zou, J Zhang, F Sun, Q Xu, L Chen, X Luo, T Wang… - Molecular …, 2024 - Springer
Background Fluvoxamine is one of the selective serotonin reuptake inhibitors (SSRIs) that
are regarded as the first-line drugs to manage mental disorders. It has been also recognized …
are regarded as the first-line drugs to manage mental disorders. It has been also recognized …
Clinical effectiveness of nirmatrelvir plus ritonavir for patients with COVID-19 and preexisting psychiatric disorders
Objectives This study assessed the clinical effectiveness of the combination of nirmatrelvir
and ritonavir (NMV-r) in treating nonhospitalized patients with COVID-19 who have …
and ritonavir (NMV-r) in treating nonhospitalized patients with COVID-19 who have …