Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts
MM Pallotta, M Di Nardo, A Musio - Cells, 2024 - mdpi.com
Cohesin is a highly conserved ring-shaped complex involved in topologically embracing
chromatids, gene expression regulation, genome compartmentalization, and genome …
chromatids, gene expression regulation, genome compartmentalization, and genome …
Unmasking the Metabolite Signature of Bladder Cancer: A Systematic Review
F Pereira, MR Domingues, R Vitorino… - International Journal of …, 2024 - mdpi.com
Bladder cancer (BCa) research relying on Omics approaches has increased over the last
few decades, improving the understanding of BCa pathology and contributing to a better …
few decades, improving the understanding of BCa pathology and contributing to a better …
[HTML][HTML] New Advances in Metastatic Urothelial Cancer: A Narrative Review on Recent Developments and Future Perspectives
E Tonni, M Oltrecolli, M Pirola, C Tchawa… - International Journal of …, 2024 - mdpi.com
The standard of care for advanced or metastatic urothelial carcinoma (mUC) was historically
identified with platinum-based chemotherapy. Thanks to the advances in biological and …
identified with platinum-based chemotherapy. Thanks to the advances in biological and …
Preclinical models of bladder cancer: BBN and beyond
Preclinical modelling is a crucial component of advancing the understanding of cancer
biology and therapeutic development. Several models exist for understanding the …
biology and therapeutic development. Several models exist for understanding the …
Dual role of GRHL3 in bladder carcinogenesis depending on histological subtypes
FC Lammert, J Pannhausen, E Noetzel… - Molecular …, 2024 - Wiley Online Library
The effect of grainyhead‐like transcription factor 3 (GRHL3) on cancer development
depends on the cancer subtypes as shown in tumor entities such as colorectal or oral …
depends on the cancer subtypes as shown in tumor entities such as colorectal or oral …
New synergistic combination therapy approaches with HDAC inhibitor quisinostat, cisplatin or PARP inhibitor talazoparib for urothelial carcinoma
S Meneceur, CE De Vos, P Petzsch… - Journal of Cellular …, 2024 - Wiley Online Library
Urothelial carcinoma (UC) urgently requires new therapeutic options. Histone deacetylases
(HDAC) are frequently dysregulated in UC and constitute interesting targets for the …
(HDAC) are frequently dysregulated in UC and constitute interesting targets for the …
Multi-omics reveals the role of ENO1 in bladder cancer and constructs an epithelial-related prognostic model to predict prognosis and efficacy
Z Su, L You, Y He, J Chen, G Zhang, Z Liu - Scientific Reports, 2024 - nature.com
Abstract α-Enolase (ENO1) is a crucial molecular target for tumor therapy and has emerged
as a research hotspot in recent decades. Here, we aimed to explore the role of ENO1 in …
as a research hotspot in recent decades. Here, we aimed to explore the role of ENO1 in …
Integration of CD4+ T cells and molecular subtype predicts benefit from PD‐L1 blockade in muscle‐invasive bladder cancer
G Liu, K Jin, Z Liu, X Su, Z Xu, B Li, J Xu, H Liu… - Cancer …, 2024 - Wiley Online Library
Muscle‐invasive bladder cancer (MIBC) is a disease characterized by molecular and clinical
heterogeneity, posing challenges in selecting the most appropriate treatment in clinical …
heterogeneity, posing challenges in selecting the most appropriate treatment in clinical …
Advancing bladder cancer management: development of a prognostic model and personalized therapy
X Huang, G Du, Y Yang, P Su, S Chen, C Cai… - Frontiers in …, 2024 - frontiersin.org
Background Bladder cancer (BLCA) was recognized as a significant public health challenge
due to its high incidence and mortality rates. The influence of molecular subtypes on …
due to its high incidence and mortality rates. The influence of molecular subtypes on …
Prognostic value of nucleotide excision repair and translesion DNA synthesis proteins in muscle-infiltrating bladder carcinoma
P Palacka, A Holíčková, J Roška, P Makovický… - BMC cancer, 2024 - Springer
Cisplatin (CDDP) remains a key agent in the treatment of muscle-infiltrating bladder
carcinoma (MIBC). However, a proportion of MIBC patients do not respond to chemotherapy …
carcinoma (MIBC). However, a proportion of MIBC patients do not respond to chemotherapy …