Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
KJM Benjamin, Q Chen, NJ Eagles… - Nature …, 2024 - nature.com
Ancestral differences in genomic variation affect the regulation of gene expression; however,
most gene expression studies have been limited to European ancestry samples or adjusted …
most gene expression studies have been limited to European ancestry samples or adjusted …
[HTML][HTML] Genetic and environmental contributions to ancestry differences in gene expression in the human brain
Ancestral differences in genomic variation are determining factors in gene regulation;
however, most gene expression studies have been limited to European ancestry samples or …
however, most gene expression studies have been limited to European ancestry samples or …
Cell subtype-specific effects of genetic variation in the Alzheimer's disease brain
The relationship between genetic variation and gene expression in brain cell types and
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data …
The end game: respecting major sources of population diversity
Human neuroscience is enjoying burgeoning population data resources: large-scale cohorts
with thousands of participant profiles of gene expression, brain scanning and …
with thousands of participant profiles of gene expression, brain scanning and …
Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex
The relationship between genetic variation and gene expression in individual brain cell
types and subtypes has remained elusive. Here, we generated single-nucleus RNA …
types and subtypes has remained elusive. Here, we generated single-nucleus RNA …
Immune and inflammatory pathways implicated by whole blood transcriptomic analysis in a diverse ancestry Alzheimer's disease cohort
AJ Griswold, SK Sivasankaran… - Journal of …, 2020 - content.iospress.com
Background: Significant work has identified genetic variants conferring risk and protection
for Alzheimer's disease (AD), but functional effects of these variants is lacking, particularly in …
for Alzheimer's disease (AD), but functional effects of these variants is lacking, particularly in …
The Caribbean-Hispanic Alzheimer's brain transcriptome reveals ancestry-specific disease mechanisms
Ethnicity impacts Alzheimer's disease risk, especially among Caribbean-Hispanics. We
report the first RNA-sequencing analysis of brain tissue from 45 Alzheimer's disease and …
report the first RNA-sequencing analysis of brain tissue from 45 Alzheimer's disease and …
Whole-genome analyses of whole-brain data: working within an expanded search space
Large-scale comparisons of patients and healthy controls have unearthed genetic risk
factors associated with a range of neurological and psychiatric illnesses. Meanwhile, brain …
factors associated with a range of neurological and psychiatric illnesses. Meanwhile, brain …
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases
Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …
variants associated with disease phenotypes. However, most of these variants do not alter …
[HTML][HTML] The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms
Identifying ancestry-specific molecular profiles of late-onset Alzheimer's Disease (LOAD) in
brain tissue is crucial to understand novel mechanisms and develop effective interventions …
brain tissue is crucial to understand novel mechanisms and develop effective interventions …