Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions
For over a century, brain research narrative has mainly centered on neuron cells.
Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their …
Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their …
[HTML][HTML] Distinctive Whole-brain Cell-Types Strongly Predict Tissue Damage Patterns in Eleven Neurodegenerative Disorders
For over a century, brain research narrative has mainly centered on neuron cells.
Accordingly, most whole-brain neurodegenerative studies focus on neuronal dysfunction …
Accordingly, most whole-brain neurodegenerative studies focus on neuronal dysfunction …
[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease
MI Gabitto, KJ Travaglini, VM Rachleff… - Research …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common cause of dementia in older adults.
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …
A single cell-based atlas of human microglial states reveals associations with neurological disorders and histopathological features of the aging brain
Recent studies of bulk microglia have provided insights into the role of this immune cell type
in central nervous system development, homeostasis and dysfunction. Nonetheless, our …
in central nervous system development, homeostasis and dysfunction. Nonetheless, our …
[HTML][HTML] Understanding the heterogeneity and spatial brain environment of neurodegenerative diseases through conventional and future methods
C Li, ML Dubbelaar, X Zhang, JC Zheng - Frontiers in Cellular …, 2023 - frontiersin.org
Neurodegenerative diseases (ND) are characterized by progressive cognitive, psychiatric,
and motor deficits due to neuronal loss of the affected brain regions (Cummings and Pillai …
and motor deficits due to neuronal loss of the affected brain regions (Cummings and Pillai …
Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer's disease
The human hippocampal formation plays a central role in Alzheimer's disease (AD)
progression, cognitive traits, and the onset of dementia; yet its molecular states in AD remain …
progression, cognitive traits, and the onset of dementia; yet its molecular states in AD remain …
Regional brain susceptibility to neurodegeneration: what is the role of glial cells?
AB Cragnolini, G Lampitella, A Virtuoso… - Neural Regeneration …, 2020 - journals.lww.com
The main pathological feature of the neurodegenerative diseases is represented by
neuronal death that represents the final step of a cascade of adverse/hostile events. Early in …
neuronal death that represents the final step of a cascade of adverse/hostile events. Early in …
[HTML][HTML] Spatial proteomics reveals human microglial states shaped by anatomy and neuropathology
Microglia are implicated in aging, neurodegeneration, and Alzheimer's disease (AD).
Traditional, low-plex, imaging methods fall short of capturing in situ cellular states and …
Traditional, low-plex, imaging methods fall short of capturing in situ cellular states and …
[HTML][HTML] Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathology
Alzheimer's disease (AD) is a neurodegenerative disorder with complex pathological
manifestations and is the leading cause of cognitive decline and dementia in elderly …
manifestations and is the leading cause of cognitive decline and dementia in elderly …
[HTML][HTML] Revealing cell vulnerability in Alzheimer's disease by single-cell transcriptomics
CA Saura, A Deprada, MD Capilla-López… - Seminars in cell & …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that by affecting specific brain cell
types and regions cause severe pathological and functional changes in memory neural …
types and regions cause severe pathological and functional changes in memory neural …