Background Variation in X chromosome inactivation (XCI) in human-induced pluripotent
stem cells (hiPSCs) can impact their ability to model biological sex biases. The gene-wise …

Epigenetic variation in the X chromosome inactivation (XCI) of human induced pluripotent
stem cells (hiPSCs) can impact their ability to accurately model biological sex biases …

Dosage compensation of sex-chromosome gene expression between male and female
mammals is achieved via X chromosome inactivation (XCI) by employing epigenetic …

X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals
whereby transcription from one X chromosome is repressed. Analysis of human induced …

Induction and reversal of chromatin silencing is critical for successful development, tissue
homeostasis, and the derivation of induced pluripotent stem cells (iPSCs). X-Chromosome …

Female human pluripotent stem cells (PSCs) have variable X-chromosome inactivation
(XCI) status. One of the X chromosomes may either be inactive (Xi) or display some active …

STUDY HYPOTHESIS Does a preferential X chromosome inactivation (XCI) pattern exist in
female human pluripotent stem cells (hPSCs) and does the pattern change during long-term …

Human pluripotent stem cells (hPSCs) display extensive epigenetic instability, particularly
on the X chromosome. In this study, we show that, in hPSCs, the inactive X chromosome has …

Generating induced pluripotent stem cells (iPSCs) requires massive epigenome
reorganization. It is unclear whether reprogramming of female human cells reactivates the …

Reprogramming somatic cells to derive induced pluripotent stem cells (iPSCs) has provided
a new method to model disease and holds great promise for regenerative medicine …