Broadly neutralizing antibodies for HIV prevention: a comprehensive review and future perspectives

S Mahomed - Clinical Microbiology Reviews, 2024 - Am Soc Microbiol
The human immunodeficiency virus (HIV) epidemic remains a formidable global health
concern, with 39 million people living with the virus and 1.3 million new infections reported …

Neutralizing antibodies for HIV-1 prevention

B Julg, DH Barouch - Current opinion in HIV and AIDS, 2019 - journals.lww.com
Encouraging results from preclinical and clinical studies support the development of bNAbs
for prevention and a number of antibodies with exceptional breadth and potency are …

Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection

YZ Cohen, M Caskey - Current Opinion in HIV and AIDS, 2018 - journals.lww.com
Summary bNAbs may offer advantages over traditional ART for both the prevention and
treatment of HIV-1 infection. In addition, bNAbs may target the latent viral reservoir. bNAb …

[HTML][HTML] The Use of Broadly Neutralizing Antibodies (bNAbs) in HIV-1 Treatment and Prevention

JJ Thavarajah, BL Hønge, CM Wejse - Viruses, 2024 - mdpi.com
Background: Although antiretroviral therapy (ART) effectively halts disease progression in
HIV infection, the complete eradication of the virus remains elusive. Additionally, challenges …

[HTML][HTML] Broadly neutralizing antibodies for HIV-1 prevention

SR Walsh, MS Seaman - Frontiers in immunology, 2021 - frontiersin.org
Given the absence of an effective vaccine for protection against HIV-1 infection, passive
immunization strategies that utilize potent broadly neutralizing antibodies (bnAbs) to block …

Clinical trials of broadly neutralizing monoclonal antibodies for human immunodeficiency virus prevention: a review

S Mahomed, N Garrett, C Baxter… - The Journal of …, 2021 - academic.oup.com
Passive immunization with broadly neutralizing antibodies (bnAbs) is a promising approach
to reduce the 1.7 million annual human immunodeficiency virus (HIV) infections globally …

Broadly neutralizing antibodies for HIV prevention

ST Karuna, L Corey - Annual review of medicine, 2020 - annualreviews.org
In the last decade, over a dozen potent broadly neutralizing antibodies (bnAbs) to several
HIV envelope protein epitopes have been identified, and their in vitro neutralization profiles …

Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection

SF Awan, M Happe, AR Hofstetter… - Current opinion in HIV …, 2022 - journals.lww.com
Broadly neutralizing antibodies for treatment and prevention... : Current Opinion in HIV and
AIDS Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection : Current …

New-generation high-potency and designer antibodies: role in HIV-1 treatment

L Gama, RA Koup - Annual review of medicine, 2018 - annualreviews.org
Broadly neutralizing antibodies (bNAbs) have been evaluated as promising agents in the
fight against infectious diseases. HIV-1-specific bNAbs, in particular, have been tested in …

Broadly neutralizing antibodies for the treatment and prevention of HIV infection

M Caskey - Current Opinion in HIV and AIDS, 2020 - journals.lww.com
Early clinical studies support additional evaluation of bNAbs. Antibodies may offer
advantages over standard ART for HIV-1 prevention and therapy, and as components of …